InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ETS2

Summary

InnateDB Gene

IDBG-3306.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ETS2

Gene Name

v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)

Synonyms

ETS2IT1

Species

Homo sapiens

Ensembl Gene

ENSG00000157557

Encoded Proteins

IDBP-3308

v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)

IDBP-3310

v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)

IDBP-365928

v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)

IDBP-365932

v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:38805307-38824955

Strand

Forward strand

Band

q22.2

Transcripts

ENST00000360214	ENSP00000353344
ENST00000360938	ENSP00000354194
ENST00000432278	ENSP00000401273
ENST00000456966	ENSP00000411086

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	36 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0035259	glucocorticoid receptor binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001501	skeletal system development
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0030154	cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022895

View Gene Order

ENSBTAG00000009214

Not yet available

Pathways

NETPATH

NetPath_5

ID pathway

NetPath_14

IL2 pathway

REACTOME

REACT_120956

Cellular responses to stress pathway

REACT_169325

Oncogene Induced Senescence pathway

REACT_169274

Cellular Senescence pathway

KEGG

hsa04320

Dorso-ventral axis formation pathway

INOH

PID NCI

cmyb_pathway

C-MYB transcription factor network

Cross-References

SwissProt

TrEMBL

C9JAG2

UniProt Splice Variant

Entrez Gene

2114

UniGene

Hs.644231 Hs.716040

RefSeq

NM_001256295 NM_005239 XM_005260935

HUGO

HGNC:3489

OMIM

164740

CCDS

CCDS13659

HPRD

01263

IMGT

EMBL

AP001040 AP001041

GenPept

RNA Seq Atlas

2114