Version 5.4
Mus musculus Gene: Tsen2
Summary
InnateDB Gene IDBG-179300.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tsen2
Gene Name tRNA splicing endonuclease 2 homolog (S. cerevisiae)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000042389
Encoded Proteins
IDBP-179302
tRNA splicing endonuclease 2 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154743:
This gene encodes one of the subunits of the tRNA splicing endonuclease. This endonuclease catalyzes the first step in RNA splicing which is the removal of introns. Mutations in this gene have been associated with pontocerebellar hypoplasia type 2. A pseudogene has been identified on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:115544664-115578350
Strand Forward strand
Band E3
Transcripts
ENSMUST00000040234 ENSMUSP00000038211
ENSMUST00000130425
ENSMUST00000123359
ENSMUST00000138200
ENSMUST00000143520
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000213 tRNA-intron endonuclease activity
GO:0003676 nucleic acid binding
GO:0016829 lyase activity
Biological Process
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation
GO:0006397 mRNA processing
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0000214 tRNA-intron endonuclease complex
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000154743
View Gene Order
ENSBTAG00000037980
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.291208
RefSeq NM_199033 XM_006506337
OMIM
CCDS CCDS20440
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca