Version 5.4
Mus musculus Gene: Ttf2
Summary
InnateDB Gene IDBG-179447.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ttf2
Gene Name transcription termination factor, RNA polymerase II
Synonyms 4632434F22Rik; 8030447N19; AV218430
Species Mus musculus
Ensembl Gene ENSMUSG00000033222
Encoded Proteins
IDBP-179451
transcription termination factor, RNA polymerase II
IDBP-541999
transcription termination factor, RNA polymerase II
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116830:
This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:100938860-100969663
Strand Reverse strand
Band F2.2
Transcripts
ENSMUST00000076941 ENSMUSP00000076208
ENSMUST00000145811
ENSMUST00000127357
ENSMUST00000151697 ENSMUSP00000119032
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
Biological Process
GO:0006200 ATP catabolic process
GO:0006353 DNA-dependent transcription, termination
GO:0006355 regulation of transcription, DNA-templated
GO:0006397 mRNA processing
GO:0008150 biological_process
GO:0008380 RNA splicing
Cellular Component
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000116830
View Gene Order
ENSBTAG00000015392
Not yet available
Cross-References
SwissProt Q5NC05
TrEMBL
UniProt Splice Variant
Entrez Gene 74044
UniGene Mm.270961 Mm.398421
RefSeq NM_001013026
OMIM
CCDS CCDS17679
HPRD
IMGT
MGI ID MGI:1921294
MGI Symbol Ttf2
EMBL AL669872 AL669937 BC087733 BC096625
GenPept AAH87733 AAH96625 CAI26225 CAM22070
RNA Seq Atlas 74044

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca