Version 5.4
Homo sapiens Gene: TTF2
Summary
InnateDB Gene IDBG-101430.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TTF2
Gene Name transcription termination factor, RNA polymerase II
Synonyms HuF2; ZGRF6
Species Homo sapiens
Ensembl Gene ENSG00000116830
Encoded Proteins
IDBP-101432
transcription termination factor, RNA polymerase II
IDBP-387896
transcription termination factor, RNA polymerase II
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:117060303-117107453
Strand Forward strand
Band p13.1
Transcripts
ENST00000369466 ENSP00000358478
ENST00000427271 ENSP00000408111
ENST00000470935
ENST00000469638
ENST00000492682
ENST00000463696
ENST00000480701
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 30 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0008094 DNA-dependent ATPase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
Biological Process
GO:0006200 ATP catabolic process
GO:0006353 DNA-dependent transcription, termination
GO:0006355 regulation of transcription, DNA-templated
GO:0006369 termination of RNA polymerase II transcription
GO:0006397 mRNA processing
GO:0008152 metabolic process
GO:0008380 RNA splicing
Cellular Component
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0008023 transcription elongation factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033222
View Gene Order
ENSBTAG00000015392
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.486818 Hs.598918
RefSeq NM_003594 XM_005271277 XM_006710981
HUGO
OMIM
CCDS CCDS892
HPRD 05280
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca