Version 5.4
| Mus musculus Gene: Gfra2 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-179520.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Gfra2 | ||||||||
| Gene Name | glial cell line derived neurotrophic factor family receptor alpha 2 | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Gene | ENSMUSG00000022103 | ||||||||
| Encoded Proteins |
glial cell line derived neurotrophic factor family receptor alpha 2
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
The protein encoded by this gene is part of the receptor complex that transduces glial cell-derived neurotrophic factor and neurturin signals by mediating autophosphorylation and activation of the RET receptor. Mice lacking this protein are viable and fertile but display growth retardation attributed to impaired salivary and pancreatic secretion and innervation deficits in the intestinal tract. In addition, knockout mice display neural defects including a failure to initiate outgrowth of dorsal ganglion root neurons, demonstrating a requirement in neuronal differentiation of these cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 14:70890130-70979838 | ||||||||
| Strand | Forward strand | ||||||||
| Band | D2 | ||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME |
NCAM1 interactions pathway
NCAM signaling for neurite out-growth pathway
Developmental Biology pathway
Axon guidance pathway
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| KEGG | |||||||||
| INOH | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | O08842 | ||||||||
| TrEMBL | Q3UET6 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 14586 | ||||||||
| UniGene | Mm.32619 | ||||||||
| RefSeq | NM_008115 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS27263 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| MGI ID | MGI:1195462 | ||||||||
| MGI Symbol | Gfra2 | ||||||||
| EMBL | AC124202 AF002701 AK138512 AK149349 BC138561 CH466535 | ||||||||
| GenPept | AAC53548 AAI38562 BAE23689 BAE28825 EDL35876 | ||||||||
| RNA Seq Atlas | 14586 | ||||||||