Version 5.4
| Homo sapiens Gene: GFRA2 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-9892.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | GFRA2 | ||||||||||||||||||
| Gene Name | GDNF family receptor alpha 2 | ||||||||||||||||||
| Synonyms | GDNFRB; NRTNR-ALPHA; NTNRA; RETL2; TRNR2 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000168546 | ||||||||||||||||||
| Encoded Proteins |
GDNF family receptor alpha 2
GDNF family receptor alpha 2
GDNF family receptor alpha 2
GDNF family receptor alpha 2
GDNF family receptor alpha 2
GDNF family receptor alpha 2
GDNF family receptor alpha 2
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 8:21690403-21812357 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | p21.3 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
NCAM1 interactions pathway
NCAM signaling for neurite out-growth pathway
Developmental Biology pathway
Axon guidance pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | O00451 | ||||||||||||||||||
| TrEMBL | E5RGR6 E5RJ44 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 2675 | ||||||||||||||||||
| UniGene | Hs.441202 Hs.720276 | ||||||||||||||||||
| RefSeq | NM_001165038 NM_001165039 NM_001495 XM_005273472 XM_005273473 XM_005273474 XM_005273475 XM_006716326 XM_006716327 | ||||||||||||||||||
| HUGO | HGNC:4244 | ||||||||||||||||||
| OMIM | 601956 | ||||||||||||||||||
| CCDS | CCDS47816 CCDS55207 | ||||||||||||||||||
| HPRD | 11801 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC105186 AC129925 AF002700 AP008236 AY326396 AY941828 BC041688 U93703 U97145 | ||||||||||||||||||
| GenPept | AAB61922 AAC51647 AAC52036 AAH41688 AAP88378 AAX46325 | ||||||||||||||||||
| RNA Seq Atlas | 2675 | ||||||||||||||||||