Version 5.4
Mus musculus Gene: Pemt
Summary
InnateDB Gene IDBG-179656.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pemt
Gene Name phosphatidylethanolamine N-methyltransferase
Synonyms PEAMT; Pempt; Pempt2; PEMT2
Species Mus musculus
Ensembl Gene ENSMUSG00000000301
Encoded Proteins
IDBP-179658
phosphatidylethanolamine N-methyltransferase
IDBP-179660
phosphatidylethanolamine N-methyltransferase
IDBP-179662
phosphatidylethanolamine N-methyltransferase
IDBP-533948
phosphatidylethanolamine N-methyltransferase
IDBP-542277
phosphatidylethanolamine N-methyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133027:
Phosphatidylcholine (PC) is the most abundant mammalian phospholipid. This gene encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. Another distinct synthetic pathway in nucleated cells converts intracellular choline to phosphatidylcholine by a three-step process. The protein isoforms encoded by this gene localize to the endoplasmic reticulum and mitochondria-associated membranes. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:59970614-60046489
Strand Reverse strand
Band B1.3
Transcripts
ENSMUST00000102693 ENSMUSP00000099754
ENSMUST00000102692 ENSMUSP00000099753
ENSMUST00000000310 ENSMUSP00000000310
ENSMUST00000150954
ENSMUST00000136660
ENSMUST00000147422 ENSMUSP00000116314
ENSMUST00000148512 ENSMUSP00000120364
ENSMUST00000143646
ENSMUST00000146461
ENSMUST00000133028
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000773 phosphatidyl-N-methylethanolamine N-methyltransferase activity
GO:0004608 phosphatidylethanolamine N-methyltransferase activity
GO:0008170 N-methyltransferase activity
GO:0080101 phosphatidyl-N-dimethylethanolamine N-methyltransferase activity
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006656 phosphatidylcholine biosynthetic process
GO:0032259 methylation
Cellular Component
GO:0005739 mitochondrion
GO:0005740 mitochondrial envelope
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000133027
View Gene Order
ENSBTAG00000016432
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00564
Glycerophospholipid metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121238
Synthesis of PC pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
INOH
INOH website
Glycine Serine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001290011 NM_001290012 NM_001290014 NM_008819
OMIM
CCDS CCDS24782
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca