InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PEMT

Summary

InnateDB Gene

IDBG-33054.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PEMT

Gene Name

phosphatidylethanolamine N-methyltransferase

Synonyms

PEAMT; PEMPT; PEMT2; PNMT

Species

Homo sapiens

Ensembl Gene

ENSG00000133027

Encoded Proteins

IDBP-33056

phosphatidylethanolamine N-methyltransferase

IDBP-238851

phosphatidylethanolamine N-methyltransferase

IDBP-238853

phosphatidylethanolamine N-methyltransferase

IDBP-238855

phosphatidylethanolamine N-methyltransferase

IDBP-371030

phosphatidylethanolamine N-methyltransferase

IDBP-763247

IDBP-761533

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Phosphatidylcholine (PC) is the most abundant mammalian phospholipid. This gene encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. Another distinct synthetic pathway in nucleated cells converts intracellular choline to phosphatidylcholine by a three-step process. The protein isoforms encoded by this gene localize to the endoplasmic reticulum and mitochondria-associated membranes. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:17505563-17591708

Strand

Reverse strand

Band

p11.2

Transcripts

ENST00000255389	ENSP00000255389
ENST00000395783	ENSP00000379129
ENST00000395782	ENSP00000379128
ENST00000395781	ENSP00000379127
ENST00000435340	ENSP00000391288
ENST00000421096
ENST00000490392
ENST00000484838
ENST00000477595
ENST00000472446
ENST00000461404	ENSP00000463713
ENST00000582268
ENST00000580147	ENSP00000463112

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000773	phosphatidyl-N-methylethanolamine N-methyltransferase activity
GO:0004608	phosphatidylethanolamine N-methyltransferase activity
GO:0008170	N-methyltransferase activity
GO:0080101	phosphatidyl-N-dimethylethanolamine N-methyltransferase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006644	phospholipid metabolic process
GO:0006656	phosphatidylcholine biosynthetic process
GO:0008283	cell proliferation
GO:0032259	methylation
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process

Cellular Component

GO:0005739	mitochondrion
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0031966	mitochondrial membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000000301

View Gene Order

ENSBTAG00000016432

Not yet available

Pathways

NETPATH

REACTOME

REACT_121238

Synthesis of PC pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_121401

Glycerophospholipid biosynthesis pathway

REACT_120870

Phospholipid metabolism pathway

REACT_111217

Metabolism pathway

KEGG

hsa00564

Glycerophospholipid metabolism pathway

INOH

INOH website

Glycine Serine metabolism pathway

PID NCI

Cross-References

SwissProt

Q9UBM1

TrEMBL

UniProt Splice Variant

Entrez Gene

10400

UniGene

RefSeq

NM_001267551 NM_148172 NM_001267552 NM_007169 NM_148173 XM_006721418

HUGO

HGNC:8830

OMIM

602391

CCDS

CCDS11186 CCDS11187 CCDS58520

HPRD

03862

IMGT

EMBL

AB029821 AC020558 AF113126 AF176806 AF176807 AF294463 AF294464 AF294465 AF294466 AF294467 AF294468 AK302251 BC000557 BC050593 CH471196 CR457099 EU574003

GenPept

AAD53291 AAD53292 AAF14867 AAH00557 AAH50593 AAK19172 ACB21050 BAA82407 BAG63603 CAG33380 EAW55701 EAW55702

RNA Seq Atlas

10400