Version 5.4
Mus musculus Gene: Cysltr2
Summary
InnateDB Gene IDBG-179703.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cysltr2
Gene Name cysteinyl leukotriene receptor 2
Synonyms 2300001H05Rik; Cltr2; Cyslt2; CYSLT2R
Species Mus musculus
Ensembl Gene ENSMUSG00000033470
Encoded Proteins
IDBP-179705
cysteinyl leukotriene receptor 2
IDBP-620454
cysteinyl leukotriene receptor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152207:
The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:73029128-73049114
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000044664 ENSMUSP00000040715
ENSMUST00000169168 ENSMUSP00000125958
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001631 cysteinyl leukotriene receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0010942 positive regulation of cell death
GO:0045766 positive regulation of angiogenesis
GO:0050909 sensory perception of taste
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000152207
View Gene Order
ENSBTAG00000017508
Not yet available
Pathways
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_230951
Leukotriene receptors pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_231468
GPCR ligand binding pathway
REACT_207651
G alpha (q) signalling events pathway
REACT_188257
Signal Transduction pathway
REACT_253164
Eicosanoid ligand-binding receptors pathway
KEGG
mmu04020
Calcium signaling pathway pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_18302
Leukotriene receptors pathway
REACT_18352
Eicosanoid ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04020
Calcium signaling pathway pathway
INOH
PID NCI
endothelinpathway
Endothelins
Cross-References
SwissProt Q920A1
TrEMBL
UniProt Splice Variant
Entrez Gene 70086
UniGene Mm.158324
RefSeq NM_001162412 NM_133720
OMIM
CCDS CCDS27265
HPRD
IMGT
MGI ID MGI:1917336
MGI Symbol Cysltr2
EMBL AF331658 BC132414 BC132418 CH466535
GenPept AAI32415 AAI32419 AAK97354 EDL35864 EDL35865
RNA Seq Atlas 70086

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca