Version 5.4
Homo sapiens Gene: CYSLTR2
Summary
InnateDB Gene IDBG-32792.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYSLTR2
Gene Name cysteinyl leukotriene receptor 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000152207
Encoded Proteins
IDBP-32794
cysteinyl leukotriene receptor 2
IDBP-810842
cysteinyl leukotriene receptor 2
IDBP-810846
cysteinyl leukotriene receptor 2
IDBP-810847
cysteinyl leukotriene receptor 2
IDBP-810848
cysteinyl leukotriene receptor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:48653711-48711226
Strand Forward strand
Band q14.2
Transcripts
ENST00000282018 ENSP00000282018
ENST00000614739 ENSP00000477930
ENST00000617562 ENSP00000482041
ENST00000622559 ENSP00000479446
ENST00000621321 ENSP00000482031
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001631 cysteinyl leukotriene receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0004974 leukotriene receptor activity
GO:0005515 protein binding
Biological Process
GO:0006955 immune response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0010942 positive regulation of cell death
GO:0045766 positive regulation of angiogenesis
GO:0050909 sensory perception of taste
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005575 cellular_component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033470
View Gene Order
ENSBTAG00000017508
Not yet available
Pathways
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_18302
Leukotriene receptors pathway
REACT_18352
Eicosanoid ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04020
Calcium signaling pathway pathway
INOH
PID NCI
endothelinpathway
Endothelins
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 57105
UniGene
RefSeq NM_020377
HUGO HGNC:18274
OMIM 605666
CCDS CCDS9412
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 57105

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca