Version 5.4
Mus musculus Gene: Ift122
Summary
InnateDB Gene IDBG-179708.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ift122
Gene Name intraflagellar transport 122
Synonyms C86139; sopb; Wdr10
Species Mus musculus
Ensembl Gene ENSMUSG00000030323
Encoded Proteins
IDBP-179710
intraflagellar transport 122 homolog (Chlamydomonas)
IDBP-254945
intraflagellar transport 122 homolog (Chlamydomonas)
IDBP-254947
intraflagellar transport 122 homolog (Chlamydomonas)
IDBP-789603
intraflagellar transport 122
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163913:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:115853470-115926699
Strand Forward strand
Band E3
Transcripts
ENSMUST00000038234 ENSMUSP00000045468
ENSMUST00000112925 ENSMUSP00000108547
ENSMUST00000112923 ENSMUSP00000108545
ENSMUST00000141305 ENSMUSP00000138535
ENSMUST00000125889
ENSMUST00000149083
ENSMUST00000138113
ENSMUST00000152092
ENSMUST00000146950
ENSMUST00000124283
ENSMUST00000155565
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0001843 neural tube closure
GO:0007227 signal transduction downstream of smoothened
GO:0009953 dorsal/ventral pattern formation
GO:0010172 embryonic body morphogenesis
GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning
GO:0035050 embryonic heart tube development
GO:0035115 embryonic forelimb morphogenesis
GO:0035720 intraciliary anterograde transport
GO:0035721 intraciliary retrograde transport
GO:0042733 embryonic digit morphogenesis
GO:0045879 negative regulation of smoothened signaling pathway
GO:0048593 camera-type eye morphogenesis
GO:0050680 negative regulation of epithelial cell proliferation
GO:0060173 limb development
GO:0060271 cilium morphogenesis
GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway
GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0060971 embryonic heart tube left/right pattern formation
GO:0061512 protein localization to cilium
GO:0072594 establishment of protein localization to organelle
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0030991 intraciliary transport particle A
GO:0032391 photoreceptor connecting cilium
GO:0036064 ciliary basal body
GO:0072372 primary cilium
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000163913
View Gene Order
ENSBTAG00000019121
Not yet available
Pathways
NETPATH
REACTOME
REACT_269412
Hedgehog 'off' state pathway
REACT_250064
Signaling by Hedgehog pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_228134
Signaling by Hedgehog pathway
REACT_111102
Signal Transduction pathway
REACT_267634
Hedgehog 'off' state pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9Q9G8 Q9ERM4
UniProt Splice Variant
Entrez Gene 81896
UniGene Mm.333335
RefSeq XM_006506797 XM_006506798 XM_006506799 NM_001167763 NM_031177
OMIM
CCDS CCDS20445 CCDS51880
HPRD
IMGT
MGI ID MGI:1932386
MGI Symbol Ift122
EMBL AC109169 AC142099 AF296075
GenPept AAG15251
RNA Seq Atlas 81896

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca