InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: IFT122

Summary

InnateDB Gene

IDBG-646352.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IFT122

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019121

Encoded Proteins

IDBP-699165

intraflagellar transport 122 homolog (Chlamydomonas)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163913:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:56881079-56948817

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000036487

ENSBTAP00000036344

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001843	neural tube closure
GO:0007227	signal transduction downstream of smoothened
GO:0009953	dorsal/ventral pattern formation
GO:0010172	embryonic body morphogenesis
GO:0021914	negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning
GO:0035050	embryonic heart tube development
GO:0035115	embryonic forelimb morphogenesis
GO:0035720	intraciliary anterograde transport
GO:0035721	intraciliary retrograde transport
GO:0042733	embryonic digit morphogenesis
GO:0045879	negative regulation of smoothened signaling pathway
GO:0048593	camera-type eye morphogenesis
GO:0050680	negative regulation of epithelial cell proliferation
GO:0060173	limb development
GO:0060271	cilium morphogenesis
GO:0060830	ciliary receptor clustering involved in smoothened signaling pathway
GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0060971	embryonic heart tube left/right pattern formation
GO:0061512	protein localization to cilium
GO:0072594	establishment of protein localization to organelle

Cellular Component

GO:0016020	membrane
GO:0030991	intraciliary transport particle A
GO:0032391	photoreceptor connecting cilium
GO:0036064	ciliary basal body
GO:0072372	primary cilium

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000163913

View Gene Order

ENSMUSG00000030323

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_228134

Signaling by Hedgehog pathway

REACT_111102

Signal Transduction pathway

REACT_267634

Hedgehog 'off' state pathway

REACT_269412

Hedgehog 'off' state pathway

REACT_250064

Signaling by Hedgehog pathway

REACT_188257

Signal Transduction pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.37431

RefSeq

XM_005223075 XM_005223076

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas