Version 5.4
Mus musculus Gene: Rho
Summary
InnateDB Gene IDBG-179854.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rho
Gene Name rhodopsin
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000030324
Encoded Proteins
IDBP-179856
rhodopsin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163914:
Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness. [provided by RefSeq, Jul 2008]
Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25%% of total cases, approximately 30%% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:115931927-115938829
Strand Forward strand
Band E3
Transcripts
ENSMUST00000032471 ENSMUSP00000032471
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0009881 photoreceptor activity
GO:0016918 retinal binding
GO:0030507 spectrin binding
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007601 visual perception
GO:0007602 phototransduction
GO:0009416 response to light stimulus
GO:0009583 detection of light stimulus
GO:0009585 red, far-red light phototransduction
GO:0016056 rhodopsin mediated signaling pathway
GO:0018298 protein-chromophore linkage
GO:0050953 sensory perception of light stimulus
GO:0060041 retina development in camera-type eye
GO:0071482 cellular response to light stimulus
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0001917 photoreceptor inner segment
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0016021 integral component of membrane
GO:0030867 rough endoplasmic reticulum membrane
GO:0042622 photoreceptor outer segment membrane
GO:0060342 photoreceptor inner segment membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000163914
View Gene Order
ENSBTAG00000001310
Not yet available
Pathways
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_189085
Disease pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_245980
Opsins pathway
REACT_231468
GPCR ligand binding pathway
REACT_250376
G alpha (i) signalling events pathway
REACT_188277
The canonical retinoid cycle in rods (twilight vision) pathway
REACT_188260
Visual phototransduction pathway
REACT_188266
Inactivation, recovery and regulation of the phototransduction cascade pathway
REACT_188265
The phototransduction cascade pathway
REACT_188257
Signal Transduction pathway
REACT_188255
Diseases associated with visual transduction pathway
REACT_188252
Activation of the phototransduction cascade pathway
KEGG
mmu04744
Phototransduction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_18426
Opsins pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_160156
The canonical retinoid cycle in rods (twilight vision) pathway
REACT_163932
Activation of the phototransduction cascade pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_160125
Visual phototransduction pathway
REACT_21340
GPCR ligand binding pathway
REACT_163722
The phototransduction cascade pathway
REACT_163919
Inactivation, recovery and regulation of the phototransduction cascade pathway
REACT_116125
Disease pathway
REACT_205369
Signaling by GPCR pathway
REACT_205562
The phototransduction cascade pathway
REACT_203536
Opsins pathway
REACT_211834
The canonical retinoid cycle in rods (twilight vision) pathway
REACT_223698
Visual phototransduction pathway
REACT_210568
G alpha (i) signalling events pathway
REACT_211562
Activation of the phototransduction cascade pathway
REACT_214353
Signal Transduction pathway
REACT_216038
Diseases associated with visual transduction pathway
REACT_214436
GPCR downstream signaling pathway
REACT_220217
GPCR ligand binding pathway
REACT_208412
Class A/1 (Rhodopsin-like receptors) pathway
REACT_207087
Disease pathway
REACT_209198
Inactivation, recovery and regulation of the phototransduction cascade pathway
KEGG
hsa04744
Phototransduction pathway
INOH
PID NCI
rhodopsin_pathway
Visual signal transduction: Rods
Cross-References
SwissProt P15409
TrEMBL
UniProt Splice Variant
Entrez Gene 212541
UniGene Mm.2965 Mm.472396
RefSeq NM_145383 XM_006505860 XM_006505861
OMIM
CCDS CCDS20446
HPRD
IMGT
MGI ID MGI:97914
MGI Symbol Rho
EMBL AK044333 AK044412 BC013125 BC031766 CH466523 M36695 M36696 M36697 M36698 M36699 M55171
GenPept AAA39861 AAA63392 AAH13125 AAH31766 BAC31871 BAC31908 EDK99545
RNA Seq Atlas 212541

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca