InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RHO

Summary

InnateDB Gene

IDBG-646351.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RHO

Gene Name

Rhodopsin

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001310

Encoded Proteins

IDBP-699145

Rhodopsin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163914:
Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness. [provided by RefSeq, Jul 2008]
Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25%% of total cases, approximately 30%% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:56867887-56872817

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000001730

ENSBTAP00000001730

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0008020	G-protein coupled photoreceptor activity
GO:0009881	photoreceptor activity
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007601	visual perception
GO:0007602	phototransduction
GO:0007603	phototransduction, visible light
GO:0009416	response to light stimulus
GO:0009583	detection of light stimulus
GO:0018298	protein-chromophore linkage
GO:0043547	positive regulation of GTPase activity
GO:0050896	response to stimulus
GO:0050909	sensory perception of taste
GO:0050953	sensory perception of light stimulus
GO:0060041	retina development in camera-type eye
GO:0071482	cellular response to light stimulus

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0001917	photoreceptor inner segment
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042622	photoreceptor outer segment membrane
GO:0060342	photoreceptor inner segment membrane
GO:0097381	photoreceptor disc membrane