InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dmap1

Summary

InnateDB Gene

IDBG-179881.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dmap1

Gene Name

DNA methyltransferase 1-associated protein 1

Synonyms

1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1; mKIAA1425

Species

Mus musculus

Ensembl Gene

ENSMUSG00000009640

Encoded Proteins

IDBP-179883

DNA methyltransferase 1-associated protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178028:
This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:117674681-117682273

Strand

Reverse strand

Band

D2.1

Transcripts

ENSMUST00000102687	ENSMUSP00000099748
ENSMUST00000135582
ENSMUST00000129510
ENSMUST00000123586
ENSMUST00000134642
ENSMUST00000127750

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	46 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006281	DNA repair
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0040008	regulation of growth
GO:0042993	positive regulation of transcription factor import into nucleus
GO:0043967	histone H4 acetylation
GO:0043968	histone H2A acetylation
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005657	replication fork
GO:0005737	cytoplasm
GO:0035267	NuA4 histone acetyltransferase complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000178028

View Gene Order

ENSBTAG00000005912

Not yet available

Pathways

NETPATH

REACTOME

REACT_218274

Chromatin organization pathway

REACT_226917

HATs acetylate histones pathway

REACT_202766

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_172610

HATs acetylate histones pathway

REACT_172623

Chromatin organization pathway

REACT_172633

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_023178 XM_006503266 XM_006503267 XM_006503268

OMIM

CCDS

CCDS18536

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas