InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dmap1

Summary

InnateDB Protein

IDBP-179883.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dmap1

Protein Name

DNA methyltransferase 1-associated protein 1

Synonyms

1500016M21Rik; Dmtap1; DNMAP1; DNMTAP1; mKIAA1425;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099748

InnateDB Gene

IDBG-179881 (Dmap1)

Protein Structure

UniProt Annotation

Function

Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX- mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Cytoplasm {ECO:0000250}. Note=Targeted to replication foci throughout S phase by DNMT1.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	46 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006281	DNA repair
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0040008	regulation of growth
GO:0042993	positive regulation of transcription factor import into nucleus
GO:0043967	histone H4 acetylation
GO:0043968	histone H2A acetylation
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005657	replication fork
GO:0005737	cytoplasm
GO:0035267	NuA4 histone acetyltransferase complex

Protein Structure and Domains

PDB ID

MGI:1913483

InterPro

IPR008468 DNA methyltransferase 1-associated 1
IPR009057 Homeodomain-like

PFAM

PF05499

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JI44

PhosphoSite

PhosphoSite-Q9JI44

TrEMBL

UniProt Splice Variant

Entrez Gene

66233

UniGene

RefSeq

NP_075667

MGI ID

MGI Symbol

Dmap1

OMIM

CCDS

CCDS18536

HPRD

IMGT

EMBL

AF265229 AF438610 AK005270 AK012055 BC002321 BC045160

GenPept

AAF87080 AAH02321 AAH45160 AAL31640 BAB27996