Version 5.4
Mus musculus Gene: Pnkp
Summary
InnateDB Gene IDBG-179919.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pnkp
Gene Name polynucleotide kinase 3'- phosphatase
Synonyms 1810009G08Rik; PNK
Species Mus musculus
Ensembl Gene ENSMUSG00000002963
Encoded Proteins
IDBP-179921
polynucleotide kinase 3'- phosphatase
IDBP-179923
polynucleotide kinase 3'- phosphatase
IDBP-265742
polynucleotide kinase 3'- phosphatase
IDBP-539880
polynucleotide kinase 3'- phosphatase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000039650:
This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.[provided by RefSeq, Sep 2010]
This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5\' phosphorylation and 3\' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.[provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:44857139-44862925
Strand Forward strand
Band B3
Transcripts
ENSMUST00000098478 ENSMUSP00000096078
ENSMUST00000003044 ENSMUSP00000003044
ENSMUST00000107876 ENSMUSP00000103508
ENSMUST00000154968 ENSMUSP00000115504
ENSMUST00000155050
ENSMUST00000145850
ENSMUST00000139003
ENSMUST00000124168
ENSMUST00000123015
ENSMUST00000152747
ENSMUST00000126860
ENSMUST00000144669
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 42 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019201 nucleotide kinase activity
GO:0046403 polynucleotide 3'-phosphatase activity
GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
Biological Process
GO:0006281 DNA repair
GO:0006979 response to oxidative stress
GO:0016311 dephosphorylation
GO:0042769 DNA damage response, detection of DNA damage
GO:0046939 nucleotide phosphorylation
GO:0098506 polynucleotide 3' dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000039650
View Gene Order
ENSBTAG00000001834
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
dnapk_pathway
DNA-PK pathway in nonhomologous end joining
Cross-References
SwissProt
TrEMBL D3YZV7
UniProt Splice Variant
Entrez Gene 59047
UniGene Mm.238254 Mm.431864 Mm.487968
RefSeq NM_001290764 NM_001290766 NM_021549 XM_006541041 XM_006541042 XM_006541044
OMIM
CCDS CCDS39945 CCDS71955
HPRD
IMGT
MGI ID MGI:1891698
MGI Symbol Pnkp
EMBL AC158231
GenPept
RNA Seq Atlas 59047

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca