Version 5.4
Mus musculus Gene: Cxcl11
Summary
InnateDB Gene IDBG-179944.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cxcl11
Gene Name chemokine (C-X-C motif) ligand 11
Synonyms b-R1; betaR1; Cxc11; H174; I-tac; Ip9; Itac; Scyb11; Scyb9b
Species Mus musculus
Ensembl Gene ENSMUSG00000060183
Encoded Proteins
IDBP-725152
IDBP-725016
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21124994
Cxcl11 exert direct antimicrobial effects in vitro against Bacillus anthracis spore and bacilli in a receptor-independent manner and contributes to pulmonary innate immunity.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type polymorphic_pseudogene
Genomic Location Chromosome 5:92359544-92365485
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000077820 ENSMUSP00000137965
ENSMUST00000122808 ENSMUSP00000137763
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 0
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008009 chemokine activity
GO:0008201 heparin binding
GO:0048248 CXCR3 chemokine receptor binding
Biological Process
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0010818 T cell chemotaxis
GO:0030816 positive regulation of cAMP metabolic process
GO:0042127 regulation of cell proliferation
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0045087 innate immune response (InnateDB)
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0060326 cell chemotaxis
GO:0070098 chemokine-mediated signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_231468
GPCR ligand binding pathway
REACT_235286
Peptide ligand-binding receptors pathway
REACT_250376
G alpha (i) signalling events pathway
REACT_230248
Chemokine receptors bind chemokines pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04620
Toll-like receptor signaling pathway pathway
mmu04062
Chemokine signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 56066
UniGene Mm.131723
RefSeq NM_019494
OMIM
CCDS
HPRD
IMGT
MGI ID MGI:1860203
MGI Symbol Cxcl11
EMBL
GenPept
RNA Seq Atlas 56066

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca