InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cxcl11

Summary

InnateDB Protein

IDBP-725152.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cxcl11

Protein Name

Synonyms

b-R1; betaR1; Cxc11; H174; I-tac; Ip9; Itac; Scyb11; Scyb9b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000137965

InnateDB Gene

IDBG-179944 (Cxcl11)

Protein Structure

UniProt Annotation

Function

Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	0
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008009	chemokine activity
GO:0008201	heparin binding
GO:0048248	CXCR3 chemokine receptor binding

Biological Process

GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0010818	T cell chemotaxis
GO:0030816	positive regulation of cAMP metabolic process
GO:0042127	regulation of cell proliferation
GO:0043950	positive regulation of cAMP-mediated signaling
GO:0045087	innate immune response (InnateDB)
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0060326	cell chemotaxis
GO:0070098	chemokine-mediated signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Protein Structure and Domains

PDB ID

MGI:1860203

InterPro

IPR001089 CXC chemokine
IPR001811 Chemokine interleukin-8-like domain

PFAM

PF00048

PRINTS

PR00437

PIRSF

SMART

SM00199

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JHH5

PhosphoSite

PhosphoSite-

TrEMBL

M0QWR7

UniProt Splice Variant

Entrez Gene

56066

UniGene

Mm.131723

RefSeq

MGI ID

MGI Symbol

Cxcl11

OMIM

CCDS

HPRD

IMGT

EMBL

AC122365 AF136449 AF167354 AF178672 AF179872

GenPept

AAF71824 AAF77095 AAF79022 AAF79048