InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cxcr7

Summary

InnateDB Gene

IDBG-179969.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cxcr7

Gene Name

chemokine (C-X-C motif) receptor 7

Synonyms

AW541270; Cmkor1; CXC-R7; CXCR-7; Cxcr7; RDC-1; Rdc1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000044337

Encoded Proteins

IDBP-179971

chemokine (C-X-C motif) receptor 7

IDBP-715313

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000144476:
This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:90203980-90216751

Strand

Forward strand

Band

Transcripts

ENSMUST00000065587	ENSMUSP00000069114
ENSMUST00000159654	ENSMUSP00000135668

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005044	scavenger receptor activity
GO:0005515	protein binding
GO:0015026	coreceptor activity
GO:0016494	C-X-C chemokine receptor activity
GO:0019958	C-X-C chemokine binding

Biological Process

GO:0001525	angiogenesis
GO:0001570	vasculogenesis
GO:0006935	chemotaxis
GO:0007155	cell adhesion
GO:0007186	G-protein coupled receptor signaling pathway
GO:0031623	receptor internalization
GO:0070098	chemokine-mediated signaling pathway
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

Cellular Component

GO:0005768	endosome
GO:0005769	early endosome
GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm
GO:0055037	recycling endosome