Mus musculus Gene: Tpm1
Summary
InnateDB Gene IDBG-180208.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tpm1
Gene Name tropomyosin 1, alpha
Synonyms AA986836; AI854628; alpha-TM; TM2; Tm3; Tmpa; Tpm-1;
Species Mus musculus
Ensembl Gene ENSMUSG00000032366
Encoded Proteins
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
Protein Structure
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140416:
This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:67022590-67049406
Strand Reverse strand
Band C
Transcripts
ENSMUST00000034928 ENSMUSP00000034928
ENSMUST00000030185 ENSMUSP00000030185
ENSMUST00000050905 ENSMUSP00000051888
ENSMUST00000113707 ENSMUSP00000109337
ENSMUST00000113705 ENSMUSP00000109335
ENSMUST00000113701 ENSMUSP00000109331
ENSMUST00000113697 ENSMUSP00000109327
ENSMUST00000113696 ENSMUSP00000109326
ENSMUST00000113695 ENSMUSP00000109325
ENSMUST00000113693 ENSMUSP00000109323
ENSMUST00000113690 ENSMUSP00000109320
ENSMUST00000113689 ENSMUSP00000109319
ENSMUST00000113687 ENSMUSP00000109317
ENSMUST00000113686 ENSMUSP00000109316
ENSMUST00000113685 ENSMUSP00000109315
ENSMUST00000113684 ENSMUSP00000109314
ENSMUST00000129733 ENSMUSP00000138784
ENSMUST00000139046 ENSMUSP00000138514
ENSMUST00000156899
ENSMUST00000129466
ENSMUST00000131279
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 41 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005200 structural constituent of cytoskeleton
GO:0008092 cytoskeletal protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0003065 positive regulation of heart rate by epinephrine
GO:0034614 cellular response to reactive oxygen species
GO:0045214 sarcomere organization
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060048 cardiac muscle contraction
Cellular Component
GO:0001725 stress fiber
GO:0005737 cytoplasm
GO:0005862 muscle thin filament tropomyosin
GO:0030016 myofibril
GO:0031941 filamentous actin
GO:0032059 bleb
GO:0032587 ruffle membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Striated Muscle Contraction pathway
Smooth Muscle Contraction pathway
Muscle contraction pathway
KEGG
Cardiac muscle contraction pathway
Hypertrophic cardiomyopathy (HCM) pathway
Dilated cardiomyopathy pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Smooth Muscle Contraction pathway
Muscle contraction pathway
Striated Muscle Contraction pathway
KEGG
Cardiac muscle contraction pathway
Hypertrophic cardiomyopathy (HCM) pathway
Dilated cardiomyopathy pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P58771
TrEMBL B7ZNL3 E9Q448 E9Q450 E9Q452 E9Q453 E9Q454 E9Q455 E9Q456 F8WID5 G5E8R0 G5E8R1 G5E8R2 Q545Y3 Q564G1 Q8BP43 Q8BSH3 S4R261 S4R2U0
UniProt Splice Variant
Entrez Gene 22003
UniGene Mm.121878 Mm.486857
RefSeq NM_001164248 NM_001164249 NM_001164250 NM_001164251 NM_001164252 NM_001164253 NM_001164254 NM_001164255 NM_001164256 NM_024427 XM_006511044 XM_006511049
OMIM
CCDS CCDS23311 CCDS52841 CCDS52842 CCDS52843 CCDS52844 CCDS52845 CCDS52846 CCDS52847 CCDS52848
HPRD
IMGT
MGI ID MGI:98809
MGI Symbol Tpm1
EMBL AC166370 AK002271 AK003175 AK032942 AK077713 AK168640 AK168783 AK169188 BC132035 BC132037 BC145307 CH466522 M22479 X64831
GenPept AAA40483 AAI32036 AAI32038 AAI45308 BAB21978 BAB22620 BAC28093 BAC36973 BAE40499 BAE40617 BAE40964 CAA46043 EDL26140 EDL26142 EDL26146 EDL26148 EDL26149 EDL26150 EDL26151
ImmGen Tpm1 (murine)
RNA Seq Atlas 22003