Mus musculus Gene: Tpm1

Summary
InnateDB Gene IDBG-180208.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol Tpm1
Gene Name tropomyosin 1, alpha
Synonyms AA986836; AI854628; alpha-TM; TM2; Tm3; Tmpa; Tpm-1
Species Mus musculus
Ensembl Gene ENSMUSG00000032366
Encoded Proteins
IDBP-180210 tropomyosin 1, alpha
IDBP-180212 tropomyosin 1, alpha
IDBP-180214 tropomyosin 1, alpha
IDBP-253308 tropomyosin 1, alpha
IDBP-253310 tropomyosin 1, alpha
IDBP-253312 tropomyosin 1, alpha
IDBP-253314 tropomyosin 1, alpha
IDBP-253316 tropomyosin 1, alpha
IDBP-253318 tropomyosin 1, alpha
IDBP-253320 tropomyosin 1, alpha
IDBP-253322 tropomyosin 1, alpha
IDBP-253324 tropomyosin 1, alpha
IDBP-253326 tropomyosin 1, alpha
IDBP-253328 tropomyosin 1, alpha
IDBP-253330 tropomyosin 1, alpha
IDBP-253332 tropomyosin 1, alpha
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140416:
This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9: 67022590-67049406
Strand Reverse strand
Band C
Transcripts
ENSMUST00000034928  ENSMUSP00000034928
ENSMUST00000030185  ENSMUSP00000030185
ENSMUST00000050905  ENSMUSP00000051888
ENSMUST00000113707  ENSMUSP00000109337
ENSMUST00000113705  ENSMUSP00000109335
ENSMUST00000113701  ENSMUSP00000109331
ENSMUST00000113697  ENSMUSP00000109327
ENSMUST00000113696  ENSMUSP00000109326
ENSMUST00000113695  ENSMUSP00000109325
ENSMUST00000113693  ENSMUSP00000109323
ENSMUST00000113690  ENSMUSP00000109320
ENSMUST00000113689  ENSMUSP00000109319
ENSMUST00000113687  ENSMUSP00000109317
ENSMUST00000113686  ENSMUSP00000109316
ENSMUST00000113685  ENSMUSP00000109315
ENSMUST00000113684  ENSMUSP00000109314
ENSMUST00000129733 
ENSMUST00000139046 
ENSMUST00000156899 
ENSMUST00000129466 
ENSMUST00000131279 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein‑Protein  7
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total 55 [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0003779 actin binding
GO:0005200 structural constituent of cytoskeleton
GO:0008092 cytoskeletal protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0003065 positive regulation of heart rate by epinephrine
GO:0009790 embryo development
GO:0034614 cellular response to reactive oxygen species
GO:0045214 sarcomere organization
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060048 cardiac muscle contraction
Cellular Component
GO:0001725 stress fiber
GO:0005737 cytoplasm
GO:0005862 muscle thin filament tropomyosin
GO:0015629 actin cytoskeleton
GO:0030016 myofibril
GO:0031941 filamentous actin
GO:0032059 bleb
GO:0032587 ruffle membrane
Orthologs
Species
Homo sapiens
Gene ID Gene Order Method Confidence Comments
ENSG00000140416 RBBH Low Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
KEGG
mmu04260  Cardiac muscle contraction
mmu05414  Dilated cardiomyopathy
mmu05410  Hypertrophic cardiomyopathy (HCM)
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_20558 Smooth Muscle Contraction
REACT_16969 Striated Muscle Contraction
KEGG
hsa04260  Cardiac muscle contraction
hsa05414  Dilated cardiomyopathy
hsa05410  Hypertrophic cardiomyopathy (HCM)
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P58771 
TrEMBL B7ZNL3 E9Q448 E9Q450 E9Q452 E9Q453 E9Q454 E9Q455 E9Q456 F8WID5 G5E8R0 G5E8R1 G5E8R2 Q545Y3 Q564G1 Q8BP43 Q8BSH3
UniProt Splice Variant
Entrez Gene 22003 
UniGene Mm.121878 Mm.486857
RefSeq NM_001164248  NM_001164249  NM_001164250  NM_001164251  NM_001164252  NM_001164253  NM_001164255  NM_001164256  NM_024427 
OMIM
CCDS CCDS23311  CCDS52841  CCDS52842  CCDS52843  CCDS52844  CCDS52845  CCDS52846  CCDS52847  CCDS52848 
HPRD
IMGT
MGI ID MGI:98809 
MGI Symbol Tpm1
EMBL AC166370 AK002271 AK003175 AK032942 AK077713 AK168640 AK168783 AK169188 BC132035 BC132037 BC145307 CH466522 M22479 X64831
GenPept AAA40483  AAI32036  AAI32038  AAI45308  BAB21978  BAB22620  BAC28093  BAC36973  BAE40499  BAE40617  BAE40964  CAA46043  EDL26140  EDL26142  EDL26146  EDL26148  EDL26149  EDL26150  EDL26151 
ImmGen Tpm1 (murine) 
RNA Seq Atlas 22003