Version 5.4
Mus musculus Gene: Ngf
Summary
InnateDB Gene IDBG-180362.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ngf
Gene Name nerve growth factor
Synonyms Ngfb
Species Mus musculus
Ensembl Gene ENSMUSG00000027859
Encoded Proteins
IDBP-180364
nerve growth factor
IDBP-267756
nerve growth factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134259:
This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]
This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene\'s expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:102469928-102521013
Strand Forward strand
Band F2.2
Transcripts
ENSMUST00000035952 ENSMUSP00000040345
ENSMUST00000106925 ENSMUSP00000102538
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005057 receptor signaling protein activity
GO:0005102 receptor binding
GO:0005163 nerve growth factor receptor binding
GO:0008083 growth factor activity
Biological Process
GO:0006954 inflammatory response
GO:0007422 peripheral nervous system development
GO:0007613 memory
GO:0007623 circadian rhythm
GO:0008284 positive regulation of cell proliferation
GO:0008344 adult locomotory behavior
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0009314 response to radiation
GO:0009612 response to mechanical stimulus
GO:0010033 response to organic substance
GO:0010193 response to ozone
GO:0010628 positive regulation of gene expression
GO:0010976 positive regulation of neuron projection development
GO:0014042 positive regulation of neuron maturation
GO:0014070 response to organic cyclic compound
GO:0019233 sensory perception of pain
GO:0030307 positive regulation of cell growth
GO:0031175 neuron projection development
GO:0031954 positive regulation of protein autophosphorylation
GO:0032496 response to lipopolysaccharide
GO:0035094 response to nicotine
GO:0035556 intracellular signal transduction
GO:0042493 response to drug
GO:0043434 response to peptide hormone
GO:0043524 negative regulation of neuron apoptotic process
GO:0045664 regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045773 positive regulation of axon extension
GO:0046928 regulation of neurotransmitter secretion
GO:0048812 neuron projection morphogenesis
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051384 response to glucocorticoid
GO:0051388 positive regulation of nerve growth factor receptor signaling pathway
GO:0051402 neuron apoptotic process
GO:0051602 response to electrical stimulus
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:2000648 positive regulation of stem cell proliferation
GO:2000675 negative regulation of type B pancreatic cell apoptotic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000134259
View Gene Order
ENSBTAG00000007446
Not yet available
Pathways
NETPATH
REACTOME
REACT_205300
PI3K/AKT activation pathway
REACT_222662
p75NTR regulates axonogenesis pathway
REACT_207546
NFG and proNGF binds to p75NTR pathway
REACT_209641
NRAGE signals death through JNK pathway
REACT_213333
TRKA activation by NGF pathway
REACT_263607
PLC-gamma1 signalling pathway
REACT_202778
Retrograde neurotrophin signalling pathway
REACT_239722
Signalling to RAS pathway
REACT_204413
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_210754
NADE modulates death signalling pathway
REACT_262560
Frs2-mediated activation pathway
REACT_214670
p75NTR recruits signalling complexes pathway
REACT_212952
Signalling to STAT3 pathway
REACT_217312
Ceramide signalling pathway
REACT_231290
Signalling to ERKs pathway
REACT_224536
p75NTR signals via NF-kB pathway
REACT_214242
Axonal growth stimulation pathway
REACT_248921
Signalling by NGF pathway
REACT_218887
NF-kB is activated and signals survival pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_234035
ARMS-mediated activation pathway
REACT_188257
Signal Transduction pathway
REACT_250933
Prolonged ERK activation events pathway
REACT_210847
p75 NTR receptor-mediated signalling pathway
REACT_206713
NGF processing pathway
REACT_202271
NRIF signals cell death from the nucleus pathway
REACT_202086
p75NTR negatively regulates cell cycle via SC1 pathway
REACT_252757
Signalling to p38 via RIT and RIN pathway
REACT_217410
Activation of TRKA receptors pathway
KEGG
mmu04010
MAPK signaling pathway pathway
mmu04210
Apoptosis pathway
mmu04722
Neurotrophin signaling pathway pathway
INOH
INOH website
NGF signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12464
PI3K/AKT activation pathway
REACT_12079
PLC-gamma1 signalling pathway
REACT_12076
Frs2-mediated activation pathway
REACT_12002
ARMS-mediated activation pathway
REACT_12077
Signalling to p38 via RIT and RIN pathway
REACT_12033
Signalling to RAS pathway
REACT_11060
TRKA activation by NGF pathway
REACT_13779
Axonal growth stimulation pathway
REACT_13415
p75NTR recruits signalling complexes pathway
REACT_13696
NF-kB is activated and signals survival pathway
REACT_13806
Ceramide signalling pathway
REACT_12049
Signalling to STAT3 pathway
REACT_12435
Retrograde neurotrophin signalling pathway
REACT_11062
NGF processing pathway
REACT_13695
p75NTR negatively regulates cell cycle via SC1 pathway
REACT_13643
NRIF signals cell death from the nucleus pathway
REACT_13526
NADE modulates death signalling pathway
REACT_13638
NRAGE signals death through JNK pathway
REACT_13724
NFG and proNGF binds to p75NTR pathway
REACT_11061
Signalling by NGF pathway
REACT_13620
p75NTR regulates axonogenesis pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_13537
p75NTR signals via NF-kB pathway
REACT_111102
Signal Transduction pathway
REACT_12058
Signalling to ERKs pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_12005
Prolonged ERK activation events pathway
REACT_11064
Activation of TRKA receptors pathway
REACT_227719
ARMS-mediated activation pathway
REACT_218381
Signalling to ERKs pathway
REACT_220289
p75NTR negatively regulates cell cycle via SC1 pathway
REACT_204563
p75NTR regulates axonogenesis pathway
REACT_202205
Retrograde neurotrophin signalling pathway
REACT_226916
Activation of TRKA receptors pathway
REACT_206309
NGF processing pathway
REACT_221742
TRKA activation by NGF pathway
REACT_216844
PLC-gamma1 signalling pathway
REACT_219752
Ceramide signalling pathway
REACT_211156
Prolonged ERK activation events pathway
REACT_226623
NRIF signals cell death from the nucleus pathway
REACT_211402
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_214353
Signal Transduction pathway
REACT_214419
Signalling to RAS pathway
REACT_221145
NF-kB is activated and signals survival pathway
REACT_225659
Signalling to p38 via RIT and RIN pathway
REACT_207949
NGF signalling via TRKA from the plasma membrane pathway
REACT_208369
NRAGE signals death through JNK pathway
REACT_210139
NFG and proNGF binds to p75NTR pathway
REACT_227494
p75NTR recruits signalling complexes pathway
REACT_207066
Signalling by NGF pathway
REACT_224179
NADE modulates death signalling pathway
REACT_218183
p75 NTR receptor-mediated signalling pathway
REACT_204115
Signalling to STAT3 pathway
REACT_225332
PI3K/AKT activation pathway
REACT_221826
Axonal growth stimulation pathway
REACT_217712
Frs2-mediated activation pathway
REACT_203904
p75NTR signals via NF-kB pathway
KEGG
hsa04210
Apoptosis pathway
hsa04010
MAPK signaling pathway pathway
hsa04722
Neurotrophin signaling pathway pathway
INOH
INOH website
NGF signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
pi3kplctrkpathway
Trk receptor signaling mediated by PI3K and PLC-gamma
trkrpathway
Neurotrophic factor-mediated Trk receptor signaling
p75ntrpathway
p75(NTR)-mediated signaling
Cross-References
SwissProt
TrEMBL Q6LDU8
UniProt Splice Variant
Entrez Gene 18049
UniGene Mm.1259
RefSeq NM_013609 XM_006501108 NM_001112698 XM_006501109 XM_006501110
OMIM
CCDS CCDS17687 CCDS51025
HPRD
IMGT
MGI ID MGI:97321
MGI Symbol Ngf
EMBL AC108822 AK144588 CH466608 K01759 M14805 M17296 M17297 M17298 M35075 S62089 V00836
GenPept AAA37686 AAA37687 AAA39818 AAA39820 AAA39821 AAB26820 BAE25950 CAA24221 EDL07615
RNA Seq Atlas 18049

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca