InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ngf

Summary

InnateDB Protein

IDBP-180364.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ngf

Protein Name

nerve growth factor

Synonyms

Ngfb;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040345

InnateDB Gene

IDBG-180362 (Ngf)

Protein Structure

UniProt Annotation

Function

Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005102	receptor binding
GO:0008083	growth factor activity

Biological Process

GO:0007422	peripheral nervous system development
GO:0007623	circadian rhythm
GO:0010976	positive regulation of neuron projection development
GO:0014042	positive regulation of neuron maturation
GO:0019233	sensory perception of pain
GO:0031954	positive regulation of protein autophosphorylation
GO:0035556	intracellular signal transduction
GO:0043524	negative regulation of neuron apoptotic process
GO:0045664	regulation of neuron differentiation
GO:0045773	positive regulation of axon extension
GO:0046928	regulation of neurotransmitter secretion
GO:0048812	neuron projection morphogenesis
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051388	positive regulation of nerve growth factor receptor signaling pathway
GO:0051402	neuron apoptotic process
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005576	extracellular region
GO:0005788	endoplasmic reticulum lumen

Protein Structure and Domains

PDB ID

MGI:97321

InterPro

IPR002072 Nerve growth factor-related
IPR020408 Nerve growth factor-like
IPR020425 Nerve growth factor, beta subunit
IPR020437 Nerve growth factor, beta subunit, mammalian
IPR029034 Cystine-knot cytokine

PFAM

PF00243

PRINTS

PR00268
PR01913
PR01925

PIRSF

PIRSF001789

SMART

SM00140

TIGRFAMs

Post-translational Modifications

Modification

Cross-References