Version 5.4
Mus musculus Gene: Lrrfip1
Summary
InnateDB Gene IDBG-180425.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lrrfip1
Gene Name leucine rich repeat (in FLII) interacting protein 1
Synonyms AU024550; Fliiap1
Species Mus musculus
Ensembl Gene ENSMUSG00000026305
Encoded Proteins
IDBP-180427
leucine rich repeat (in FLII) interacting protein 1
IDBP-180429
leucine rich repeat (in FLII) interacting protein 1
IDBP-180431
leucine rich repeat (in FLII) interacting protein 1
IDBP-180433
leucine rich repeat (in FLII) interacting protein 1
IDBP-788905
leucine rich repeat (in FLII) interacting protein 1
IDBP-788907
leucine rich repeat (in FLII) interacting protein 1
IDBP-788908
leucine rich repeat (in FLII) interacting protein 1
IDBP-788912
leucine rich repeat (in FLII) interacting protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 20453844
[Homo sapiens] LRRFIP1 interacts with and activates beta-catenin, which increases IFN-beta expression by binding to the C-terminal domain of the transcription factor IRF3 and recruiting the acetyltransferase EP300 to the IFN-beta enhanceosome via IRF3.
PMID 16199883
[Homo sapiens] LRRFIP1 (GCF2) acts as a repressor and occupies the -308 site of the TNF-alpha promoter in cells that do not make TNF-alpha. Other proteins may bind to the promoter, particular to the -308 site to transition from repressed to active transcription.
PMID 21102652
[Homo sapiens] LRRFIP1 is a regulator of toll-like receptor (TLR) pathway signaling and it co-localized with dsRNA in monocyte lysosomal structures.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124831:
Gene Information
Type Protein coding
Genomic Location Chromosome 1:90998737-91128944
Strand Forward strand
Band D
Transcripts
ENSMUST00000068116 ENSMUSP00000065850
ENSMUST00000068167 ENSMUSP00000063878
ENSMUST00000097650 ENSMUSP00000095255
ENSMUST00000097649 ENSMUSP00000095254
ENSMUST00000189505 ENSMUSP00000141024
ENSMUST00000185531 ENSMUSP00000139497
ENSMUST00000186762 ENSMUSP00000139902
ENSMUST00000189617 ENSMUSP00000139811
ENSMUST00000188094
ENSMUST00000188708
ENSMUST00000187375
ENSMUST00000187532
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000124831
View Gene Order
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_230745
Immune System pathway
REACT_223626
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production pathway
REACT_218897
Cytosolic sensors of pathogen-associated DNA pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_24
TSLP pathway
REACTOME
REACT_121141
Signaling by FGFR1 fusion mutants pathway
REACT_121398
Signaling by FGFR mutants pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_163743
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production pathway
REACT_6802
Innate Immune System pathway
REACT_120999
Signaling by FGFR1 mutants pathway
REACT_6900
Immune System pathway
REACT_118823
Cytosolic sensors of pathogen-associated DNA pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 16978
UniGene
RefSeq NM_001111311 NM_001111312 NM_008515 XM_006529192 XM_006529208 XM_006529210 XM_006529212
OMIM
CCDS CCDS35662 CCDS48319 CCDS48320
HPRD
IMGT
MGI ID MGI:1342770
MGI Symbol Lrrfip1
EMBL
GenPept
RNA Seq Atlas 16978

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca