Version 5.4
Mus musculus Gene: Myo15
Summary
InnateDB Gene IDBG-180576.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Myo15
Gene Name myosin XV
Synonyms Myo15a; sh-2; sh2
Species Mus musculus
Ensembl Gene ENSMUSG00000042678
Encoded Proteins
IDBP-180578
myosin XV
IDBP-180582
myosin XV
IDBP-180584
myosin XV
IDBP-536665
myosin XV
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000091536:
This gene encodes an unconventional myosin. This protein differs from other myosins in that it has a long N-terminal extension preceding the conserved motor domain. Studies in mice suggest that this protein is necessary for actin organization in the hair cells of the cochlea. Mutations in this gene have been associated with profound, congenital, neurosensory, nonsyndromal deafness. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Read-through transcripts containing an upstream gene and this gene have been identified, but they are not thought to encode a fusion protein. Several alternatively spliced transcript variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:60469339-60528369
Strand Forward strand
Band B2
Transcripts
ENSMUST00000071880 ENSMUSP00000071777
ENSMUST00000081823 ENSMUSP00000080507
ENSMUST00000094135 ENSMUSP00000091686
ENSMUST00000126522 ENSMUSP00000120839
ENSMUST00000122825
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003774 motor activity
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0007605 sensory perception of sound
GO:0007626 locomotory behavior
GO:0008152 metabolic process
GO:0042472 inner ear morphogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0016459 myosin complex
GO:0032420 stereocilium
GO:0032421 stereocilium bundle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000091536
View Gene Order
ENSBTAG00000006520
Not yet available
Cross-References
SwissProt Q9QZZ4
TrEMBL
UniProt Splice Variant
Entrez Gene 17910
UniGene Mm.89960
RefSeq NM_010862 XM_006532427 NM_001103171 NM_182698 XM_006532422 XM_006532428
OMIM
CCDS CCDS24792 CCDS24793 CCDS48811
HPRD
IMGT
MGI ID MGI:1261811
MGI Symbol Myo15
EMBL AB014510 AF053130 AF144095 AL596090 AL596386 AY331132 AY331133
GenPept AAC40124 AAF05904 AAP88402 AAP88403 BAA36582 CAI24082 CAI35347 CAM14761 CAM14762 CAM21169 CAM21170
RNA Seq Atlas 17910

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca