InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Myo15

Summary

InnateDB Protein

IDBP-180578.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myo15

Protein Name

myosin XV

Synonyms

Myo15a; sh-2; sh2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000071777

InnateDB Gene

IDBG-180576 (Myo15)

Protein Structure

UniProt Annotation

Function

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). Required for the arrangement of stereocilia in mature hair bundles. {ECO:0000250, ECO:0000269PubMed:14610277, ECO:0000269PubMed:15654330}.

Subcellular Localization

Cell projection, stereocilium {ECO:0000269PubMed:14610277}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:14610277}. Note=Localizes to stereocilium tips in cochlear and vestibular hair cells.

Disease Associations

Note=Defects in Myo15a are the cause of shaker-2 (sh-2), a condition causing deafness, circling behavior, head tossing and hyperactivity. Auditory hair cells of affected animals have very short stereocilia and a long actin-containing protrusion at their basal end.

Tissue Specificity

In the developing inner ear, expressed in cochlea and vestibular apparatus. Expression appears to be restricted to cochlear neurosensory cells and upper epithelial layer of macula saccula. Also expressed in macula utriculi and cristae ampullaris of the semicircular canals. In adult cochlear hair cells, highest expression in stereocilia and apical body. {ECO:0000269PubMed:10552926}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0007605	sensory perception of sound
GO:0007626	locomotory behavior
GO:0008152	metabolic process
GO:0042472	inner ear morphogenesis

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0016459	myosin complex
GO:0032420	stereocilium
GO:0032421	stereocilium bundle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1261811

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR000299 FERM domain
IPR000857 MyTH4 domain
IPR001452 SH3 domain
IPR001609 Myosin head, motor domain
IPR011511 Variant SH3 domain
IPR019748 FERM central domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029071 Ubiquitin-related domain

PFAM