Version 5.4
Mus musculus Gene: Ripk4
Summary
InnateDB Gene IDBG-180710.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ripk4
Gene Name receptor-interacting serine-threonine kinase 4
Synonyms 2310069J12Rik; AI552420; ANKK2; Ankrd3; DIk; PKK; RIP4
Species Mus musculus
Ensembl Gene ENSMUSG00000005251
Encoded Proteins
IDBP-180712
receptor-interacting serine-threonine kinase 4
IDBP-253231
receptor-interacting serine-threonine kinase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183421:
The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:97741933-97763737
Strand Reverse strand
Band C4
Transcripts
ENSMUST00000019386 ENSMUSP00000019386
ENSMUST00000113743 ENSMUSP00000109372
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0002009 morphogenesis of an epithelium
GO:0006468 protein phosphorylation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000183421
View Gene Order
ENSBTAG00000021251
Not yet available
Cross-References
SwissProt Q9ERK0
TrEMBL D3YXY4 Q9CV04
UniProt Splice Variant
Entrez Gene 72388
UniGene Mm.35290
RefSeq NM_023663
OMIM
CCDS CCDS28360
HPRD
IMGT
MGI ID MGI:1919638
MGI Symbol Ripk4
EMBL AC121560 AF302127 AK010133 AK145203 BC057871
GenPept AAG30871 AAH57871 BAB26721 BAE26294
RNA Seq Atlas 72388

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca