InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ripk4

Summary

InnateDB Protein

IDBP-180712.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ripk4

Protein Name

receptor-interacting serine-threonine kinase 4

Synonyms

2310069J12Rik; AI552420; ANKK2; Ankrd3; DIk; PKK; RIP4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000019386

InnateDB Gene

IDBG-180710 (Ripk4)

Protein Structure

UniProt Annotation

Function

Involved in stratified epithelial development (By similarity). It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation. {ECO:0000250, ECO:0000269PubMed:12446564, ECO:0000269PubMed:22197488}.

Subcellular Localization

Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state, a minor portion of this protein is membrane-associated. The major portion is cytoplasmic.

Disease Associations

Tissue Specificity

Ubiquitously expressed, with an abundant expression in the thymus, bone marrow, pro-B, pre-B and immature B cells and a weak expression in the spleen. {ECO:0000269PubMed:11278382}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0002009	morphogenesis of an epithelium
GO:0006468	protein phosphorylation
GO:0051092	positive regulation of NF-kappaB transcription factor activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1919638

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002110 Ankyrin repeat
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00069
PF07714
PF00023
PF13606
PF11929
PF12796

PRINTS

PR00109
PR01415

PIRSF

SMART

SM00248
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt