Version 5.4
Mus musculus Gene: Scly
Summary
InnateDB Gene IDBG-180741.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Scly
Gene Name selenocysteine lyase
Synonyms 9830169H08; A930015N15Rik; SCL; Scly1; Scly2
Species Mus musculus
Ensembl Gene ENSMUSG00000026307
Encoded Proteins
IDBP-180743
selenocysteine lyase
IDBP-542059
selenocysteine lyase
IDBP-714123
IDBP-541382
selenocysteine lyase
IDBP-542068
selenocysteine lyase
IDBP-542798
selenocysteine lyase
IDBP-532091
selenocysteine lyase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132330:
Selenocysteine lyase (SCLY; EC 4.4.1.16) catalyzes the pyridoxal 5-prime phosphate-dependent conversion of L-selenocysteine to L-alanine and elemental selenium (Mihara et al., 2000 [PubMed 10692412]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:91298338-91321075
Strand Forward strand
Band D
Transcripts
ENSMUST00000027532 ENSMUSP00000027532
ENSMUST00000123651
ENSMUST00000142488 ENSMUSP00000119979
ENSMUST00000154045 ENSMUSP00000137796
ENSMUST00000153621
ENSMUST00000124832 ENSMUSP00000116382
ENSMUST00000147523 ENSMUSP00000114759
ENSMUST00000142802
ENSMUST00000145843 ENSMUSP00000116824
ENSMUST00000137074 ENSMUSP00000122449
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0009000 selenocysteine lyase activity
GO:0016740 transferase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0001887 selenium compound metabolic process
GO:0006629 lipid metabolic process
GO:0008152 metabolic process
GO:0032868 response to insulin
GO:1900408 negative regulation of cellular response to oxidative stress
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000132330
View Gene Order
ENSBTAG00000017826
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00450
Selenocompound metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00450
Selenocompound metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL M0QWF1
UniProt Splice Variant
Entrez Gene 50880
UniGene Mm.25724 Mm.442172
RefSeq NM_016717 XM_006529743 XM_006529744 XM_006529745 XM_006529746
OMIM
CCDS CCDS15159
HPRD
IMGT
MGI ID MGI:1355310
MGI Symbol Scly
EMBL AC102874 AC110510
GenPept
RNA Seq Atlas 50880

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca