InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Scly

Summary

InnateDB Protein

IDBP-180743.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scly

Protein Name

selenocysteine lyase

Synonyms

9830169H08; A930015N15Rik; SCL; Scly1; Scly2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027532

InnateDB Gene

IDBG-180741 (Scly)

Protein Structure

UniProt Annotation

Function

Catalyzes the decomposition of L-selenocysteine to L- alanine and elemental selenium. {ECO:0000269PubMed:10692412}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:10692412}.

Disease Associations

Tissue Specificity

Widely expressed. Present in liver, kidney, testis (at protein level). {ECO:0000269PubMed:10692412}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0009000	selenocysteine lyase activity
GO:0016740	transferase activity
GO:0030170	pyridoxal phosphate binding

Biological Process

GO:0001887	selenium compound metabolic process
GO:0006629	lipid metabolic process
GO:0008152	metabolic process
GO:0032868	response to insulin
GO:1900408	negative regulation of cellular response to oxidative stress