Version 5.4
Mus musculus Gene: Ptprf
Summary
InnateDB Gene IDBG-180768.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ptprf
Gene Name protein tyrosine phosphatase, receptor type, F
Synonyms AA591035; LAR; LARS; RPTP-LAR
Species Mus musculus
Ensembl Gene ENSMUSG00000033295
Encoded Proteins
IDBP-180770
protein tyrosine phosphatase, receptor type, F
IDBP-543054
protein tyrosine phosphatase, receptor type, F
IDBP-543055
protein tyrosine phosphatase, receptor type, F
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142949:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:118208213-118291405
Strand Reverse strand
Band D2.1
Transcripts
ENSMUST00000049074 ENSMUSP00000039368
ENSMUST00000123484
ENSMUST00000150096 ENSMUSP00000117313
ENSMUST00000124758 ENSMUSP00000119954
ENSMUST00000127616
ENSMUST00000143348
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0016791 phosphatase activity
GO:0032403 protein complex binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0007155 cell adhesion
GO:0016311 dephosphorylation
GO:0016477 cell migration
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:1900121 negative regulation of receptor binding
Cellular Component
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000142949
View Gene Order
ENSBTAG00000000253
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04514
Cell adhesion molecules (CAMs) pathway
mmu04910
Insulin signaling pathway pathway
mmu04520
Adherens junction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04520
Adherens junction pathway
hsa04910
Insulin signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt A2A8L5
TrEMBL Q3TT24 Q3V0J9 Q4JFB8 Q4U1Z0 Q64696
UniProt Splice Variant
Entrez Gene 19268
UniGene Mm.29855 Mm.467672
RefSeq NM_011213 XM_006502870 XM_006502866 XM_006502868 XM_006502876
OMIM
CCDS CCDS18546
HPRD
IMGT
MGI ID MGI:102695
MGI Symbol Ptprf
EMBL AF300943 AK133085 AK161629 AL626764 AL807774 BC057166 Z23049 Z23061 Z37988
GenPept AAG40194 AAH57166 BAE21505 BAE36501 CAA80584 CAA80596 CAA86070 CAM17264 CAM27382
RNA Seq Atlas 19268

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca