InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptprf

Summary

InnateDB Protein

IDBP-180770.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptprf

Protein Name

protein tyrosine phosphatase, receptor type, F

Synonyms

AA591035; LAR; LARS; RPTP-LAR;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000039368

InnateDB Gene

IDBG-180768 (Ptprf)

Protein Structure

UniProt Annotation

Function

Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in the cell of the T lineage but not in cells of any other hemopoietic lineage. {ECO:0000269PubMed:11241288}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0016791	phosphatase activity
GO:0032403	protein complex binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0007155	cell adhesion
GO:0016311	dephosphorylation
GO:0016477	cell migration
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:1900121	negative regulation of receptor binding

Cellular Component

GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:102695

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00041
PF01108
PF07679

PRINTS

PR00700

PIRSF

SMART

SM00194
SM00404
SM00408
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt