InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GPRC5B

Summary

InnateDB Gene

IDBG-18080.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPRC5B

Gene Name

G protein-coupled receptor, family C, group 5, member B

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000167191

Encoded Proteins

IDBP-18082

G protein-coupled receptor, family C, group 5, member B

IDBP-601069

G protein-coupled receptor, family C, group 5, member B

IDBP-745003

IDBP-746727

IDBP-748986

IDBP-745597

IDBP-749728

IDBP-752325

IDBP-746808

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:19856691-19886167

Strand

Reverse strand

Band

p12.3

Transcripts

ENST00000300571	ENSP00000300571
ENST00000535671	ENSP00000442858
ENST00000566822	ENSP00000454667
ENST00000562348
ENST00000570142	ENSP00000456724
ENST00000564449	ENSP00000457018
ENST00000568214	ENSP00000457080
ENST00000569847	ENSP00000457283
ENST00000562469	ENSP00000455960
ENST00000569479	ENSP00000454727
ENST00000569102

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0004930	G-protein coupled receptor activity
GO:0019901	protein kinase binding
GO:0030295	protein kinase activator activity

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007626	locomotory behavior
GO:0010976	positive regulation of neuron projection development
GO:0042593	glucose homeostasis
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045666	positive regulation of neuron differentiation
GO:0045860	positive regulation of protein kinase activity
GO:0050729	positive regulation of inflammatory response
GO:0060907	positive regulation of macrophage cytokine production
GO:0061098	positive regulation of protein tyrosine kinase activity
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000008734

View Gene Order

ENSBTAG00000019596

Not yet available

Cross-References

SwissProt

TrEMBL

H3BN33 H3BQV9 H3BSJ1 H3BT47 H3BT93

UniProt Splice Variant

Entrez Gene

51704

UniGene

Hs.148685 Hs.613036 Hs.656664 Hs.737868

RefSeq

NM_016235 XM_006721051 XM_006721052

HUGO

HGNC:13308

OMIM

605948

CCDS

CCDS10581

HPRD

16177

IMGT

EMBL

AC134300

GenPept

RNA Seq Atlas

51704