Version 5.4
Mus musculus Gene: Ilkap
Summary
InnateDB Gene IDBG-181075.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ilkap
Gene Name integrin-linked kinase-associated serine/threonine phosphatase 2C
Synonyms 0710007A14Rik; 1600009O09Rik; PP2C-DELTA
Species Mus musculus
Ensembl Gene ENSMUSG00000026309
Encoded Proteins
IDBP-181077
integrin-linked kinase-associated serine/threonine phosphatase 2C
IDBP-790012
integrin-linked kinase-associated serine/threonine phosphatase 2C
IDBP-790013
integrin-linked kinase-associated serine/threonine phosphatase 2C
IDBP-790014
integrin-linked kinase-associated serine/threonine phosphatase 2C
IDBP-790015
integrin-linked kinase-associated serine/threonine phosphatase 2C
IDBP-790016
integrin-linked kinase-associated serine/threonine phosphatase 2C
IDBP-790017
integrin-linked kinase-associated serine/threonine phosphatase 2C
IDBP-790018
integrin-linked kinase-associated serine/threonine phosphatase 2C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132323:
The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:91373861-91398815
Strand Reverse strand
Band D
Transcripts
ENSMUST00000027534 ENSMUSP00000027534
ENSMUST00000187049 ENSMUSP00000140752
ENSMUST00000190747 ENSMUSP00000140905
ENSMUST00000187105
ENSMUST00000187231 ENSMUSP00000139962
ENSMUST00000185886
ENSMUST00000187306 ENSMUSP00000139834
ENSMUST00000187678 ENSMUSP00000140182
ENSMUST00000191230
ENSMUST00000186986 ENSMUSP00000140074
ENSMUST00000186433
ENSMUST00000190519 ENSMUSP00000140048
ENSMUST00000189651
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0033262 regulation of nuclear cell cycle DNA replication
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000132323
View Gene Order
ENSBTAG00000010176
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
ilk_pathway
Integrin-linked kinase signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_023343 XM_006529807 XM_006529808 XM_006529809 XM_006529814 XM_006529815 XM_006529816
OMIM
CCDS CCDS15162
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca