Version 5.4
Homo sapiens Gene: ILKAP
Summary
InnateDB Gene IDBG-84481.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ILKAP
Gene Name integrin-linked kinase-associated serine/threonine phosphatase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000132323
Encoded Proteins
IDBP-84483
integrin-linked kinase-associated serine/threonine phosphatase
IDBP-389534
integrin-linked kinase-associated serine/threonine phosphatase
IDBP-389535
integrin-linked kinase-associated serine/threonine phosphatase
IDBP-813332
integrin-linked kinase-associated serine/threonine phosphatase
IDBP-813333
integrin-linked kinase-associated serine/threonine phosphatase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:238170401-238203729
Strand Reverse strand
Band q37.3
Transcripts
ENST00000254654 ENSP00000254654
ENST00000450411 ENSP00000406254
ENST00000457149 ENSP00000395301
ENST00000465131
ENST00000463129
ENST00000466468
ENST00000479400
ENST00000498727
ENST00000467133
ENST00000490837
ENST00000622223 ENSP00000477542
ENST00000612675 ENSP00000477533
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0008152 metabolic process
GO:0033262 regulation of nuclear cell cycle DNA replication
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026309
View Gene Order
ENSBTAG00000010176
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
ilk_pathway
Integrin-linked kinase signaling
Cross-References
SwissProt Q9H0C8
TrEMBL E9PC05 F8SNU6 F8SNU7 H7C2I8
UniProt Splice Variant
Entrez Gene 80895
UniGene Hs.92033
RefSeq NM_030768 XM_005246106 XM_006712784
HUGO HGNC:15566
OMIM
CCDS CCDS2526
HPRD
IMGT
EMBL AC016757 AK001043 AL136850 AY024365 BC006576 CR533533 HQ658059 HQ658060
GenPept AAH06576 AAK07736 AAY24336 AEI30977 AEI30978 BAG50851 CAB66784 CAG38564
RNA Seq Atlas 102724454 80895

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca