Version 5.4
Mus musculus Gene: Hdac4
Summary
InnateDB Gene IDBG-181579.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hdac4
Gene Name histone deacetylase 4
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000026313
Encoded Proteins
IDBP-181583
histone deacetylase 4
IDBP-789919
histone deacetylase 4
IDBP-789920
histone deacetylase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000068024:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:91928779-92180341
Strand Reverse strand
Band D
Transcripts
ENSMUST00000008995 ENSMUSP00000008995
ENSMUST00000189303
ENSMUST00000191327
ENSMUST00000187308 ENSMUSP00000140092
ENSMUST00000189730
ENSMUST00000185267
ENSMUST00000186002 ENSMUSP00000141018
ENSMUST00000185341
ENSMUST00000187622
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 182 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 24 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 182 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001047 core promoter binding
GO:0003677 DNA binding
GO:0003714 transcription corepressor activity
GO:0004407 histone deacetylase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0019901 protein kinase binding
GO:0030955 potassium ion binding
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033558 protein deacetylase activity
GO:0033613 activating transcription factor binding
GO:0042826 histone deacetylase binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0070491 repressing transcription factor binding
GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001501 skeletal system development
GO:0002076 osteoblast development
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0010832 negative regulation of myotube differentiation
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
GO:0014894 response to denervation involved in regulation of muscle adaptation
GO:0016568 chromatin modification
GO:0016575 histone deacetylation
GO:0033235 positive regulation of protein sumoylation
GO:0034983 peptidyl-lysine deacetylation
GO:0042493 response to drug
GO:0043393 regulation of protein binding
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045668 negative regulation of osteoblast differentiation
GO:0045820 negative regulation of glycolytic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048742 regulation of skeletal muscle fiber development
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051153 regulation of striated muscle cell differentiation
GO:0070555 response to interleukin-1
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0017053 transcriptional repressor complex
GO:0030017 sarcomere
GO:0030018 Z disc
GO:0031594 neuromuscular junction
GO:0031672 A band
GO:0042641 actomyosin
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000068024
View Gene Order
ENSBTAG00000017764
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118780
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_160243
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_160254
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_299
Signaling by NOTCH pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_116125
Disease pathway
KEGG
INOH
INOH website
TGF-beta signaling pathway
PID NCI
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
hdac_classii_pathway
Signaling events mediated by HDAC Class II
hdac_classiii_pathway
Signaling events mediated by HDAC Class III
ranbp2pathway
Sumoylation by RanBP2 regulates transcriptional repression
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_207225 XM_006529302 XM_006529303 XM_006529304 XM_006529305 XM_006529306 XM_006529307 XM_006529308 XM_006529309 XM_006529311 XM_006529312 XM_006529313 XM_006529314 XM_006529315 XM_006529316
OMIM
CCDS CCDS48324
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca