InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: HDAC4

Summary

InnateDB Gene

IDBG-642244.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HDAC4

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017764

Encoded Proteins

IDBP-694724

histone deacetylase 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000068024:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:118937215-119412428

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000023621

ENSBTAP00000023621

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 185 interaction(s) predicted by orthology.

Predicted by orthology
Total	185 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0004407	histone deacetylase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0019901	protein kinase binding
GO:0030955	potassium ion binding
GO:0033558	protein deacetylase activity
GO:0033613	activating transcription factor binding
GO:0042826	histone deacetylase binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0070491	repressing transcription factor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001501	skeletal system development
GO:0002076	osteoblast development
GO:0006338	chromatin remodeling
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0010832	negative regulation of myotube differentiation
GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling
GO:0014894	response to denervation involved in regulation of muscle adaptation
GO:0016568	chromatin modification
GO:0016575	histone deacetylation
GO:0033235	positive regulation of protein sumoylation
GO:0034983	peptidyl-lysine deacetylation
GO:0043393	regulation of protein binding
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045668	negative regulation of osteoblast differentiation
GO:0045820	negative regulation of glycolytic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048742	regulation of skeletal muscle fiber development
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051153	regulation of striated muscle cell differentiation
GO:0070555	response to interleukin-1
GO:0070932	histone H3 deacetylation
GO:0070933	histone H4 deacetylation

Cellular Component

GO:0000118	histone deacetylase complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0017053	transcriptional repressor complex
GO:0031594	neuromuscular junction
GO:0042641	actomyosin