Version 5.4
Mus musculus Gene: Cnksr2
Summary
InnateDB Gene IDBG-181958.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cnksr2
Gene Name connector enhancer of kinase suppressor of Ras 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000025658
Encoded Proteins
IDBP-181960
connector enhancer of kinase suppressor of Ras 2
IDBP-255851
connector enhancer of kinase suppressor of Ras 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149970:
This gene encodes a multidomain protein that functions as a scaffold protein to mediate the mitogen-activated protein kinase pathways downstream from Ras. This gene product is induced by vitamin D and inhibits apoptosis in certain cancer cells. It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:157821436-158043294
Strand Reverse strand
Band F4
Transcripts
ENSMUST00000026750 ENSMUSP00000026750
ENSMUST00000112513 ENSMUSP00000108132
ENSMUST00000139664
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0009966 regulation of signal transduction
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0045211 postsynaptic membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000149970
View Gene Order
ENSBTAG00000044202
Not yet available
Cross-References
SwissProt Q80YA9
TrEMBL A2AI78
UniProt Splice Variant
Entrez Gene 245684
UniGene Mm.408631 Mm.411095 Mm.488878
RefSeq NM_177751
OMIM
CCDS CCDS30501
HPRD
IMGT
MGI ID MGI:2661175
MGI Symbol Cnksr2
EMBL AK122399 AL732396 AL807779 BC043093 BC060716
GenPept AAH43093 AAH60716 BAC65681
RNA Seq Atlas 245684

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca