Version 5.4
Mus musculus Gene: Prph
Summary
InnateDB Gene IDBG-182090.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prph
Gene Name peripherin
Synonyms Prph1
Species Mus musculus
Ensembl Gene ENSMUSG00000023484
Encoded Proteins
IDBP-182092
peripherin
IDBP-182094
peripherin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135406:
This gene encodes a cytoskeletal protein found in neurons of the peripheral nervous system. The encoded protein is a type III intermediate filament protein with homology to other cytoskeletal proteins such as desmin, and is a different protein that the peripherin found in photoreceptors. Mutations in this gene have been associated with susceptibility to amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:99055174-99058978
Strand Forward strand
Band F1
Transcripts
ENSMUST00000047104 ENSMUSP00000049303
ENSMUST00000024249 ENSMUSP00000024249
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
Biological Process
GO:0045104 intermediate filament cytoskeleton organization
Cellular Component
GO:0005882 intermediate filament
GO:0005883 neurofilament
GO:0016020 membrane
GO:0030424 axon
GO:0042622 photoreceptor outer segment membrane
GO:0043025 neuronal cell body
GO:0044299 C-fiber
GO:0045098 type III intermediate filament
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000135406
View Gene Order
ENSBTAG00000017864
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu05014
Amyotrophic lateral sclerosis (ALS) pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa05014
Amyotrophic lateral sclerosis (ALS) pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL G3X981 G5E846
UniProt Splice Variant
Entrez Gene 19132
UniGene Mm.2477
RefSeq NM_001163588 NM_001163589 NM_013639 XM_006520631
OMIM
CCDS CCDS27813 CCDS49727
HPRD
IMGT
MGI ID MGI:97774
MGI Symbol Prph
EMBL AC157610 CH466550
GenPept EDL04147 EDL04148
RNA Seq Atlas 19132

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca