InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Aldh3a2

Summary

InnateDB Gene

IDBG-182466.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aldh3a2

Gene Name

aldehyde dehydrogenase family 3, subfamily A2

Synonyms

Ahd-3; Ahd-3r; Ahd3; Ahd3-r; AI194803; Aldh4; Aldh4-r; FALDH

Species

Mus musculus

Ensembl Gene

ENSMUSG00000010025

Encoded Proteins

IDBP-182468

aldehyde dehydrogenase family 3, subfamily A2

IDBP-182470

aldehyde dehydrogenase family 3, subfamily A2

IDBP-263949

aldehyde dehydrogenase family 3, subfamily A2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072210:
Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:61223417-61267464

Strand

Reverse strand

Band

Transcripts

ENSMUST00000066277	ENSMUSP00000067767
ENSMUST00000074127	ENSMUSP00000073764
ENSMUST00000108715	ENSMUSP00000104355
ENSMUST00000141368
ENSMUST00000147291
ENSMUST00000128991
ENSMUST00000149298

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003995	acyl-CoA dehydrogenase activity
GO:0004029	aldehyde dehydrogenase (NAD) activity
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity
GO:0016491	oxidoreductase activity
GO:0046577	long-chain-alcohol oxidase activity
GO:0050061	long-chain-aldehyde dehydrogenase activity
GO:0052814	medium-chain-aldehyde dehydrogenase activity

Biological Process

GO:0006081	cellular aldehyde metabolic process
GO:0006714	sesquiterpenoid metabolic process
GO:0007417	central nervous system development
GO:0007422	peripheral nervous system development
GO:0008152	metabolic process
GO:0008218	bioluminescence
GO:0008544	epidermis development
GO:0033306	phytol metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005777	peroxisome
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome