InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aldh3a2

Summary

InnateDB Protein

IDBP-182470.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aldh3a2

Protein Name

aldehyde dehydrogenase family 3, subfamily A2

Synonyms

Ahd-3; Ahd-3r; Ahd3; Ahd3-r; AI194803; Aldh4; Aldh4-r; FALDH;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000073764

InnateDB Gene

IDBG-182466 (Aldh3a2)

Protein Structure

UniProt Annotation

Function

Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003995	acyl-CoA dehydrogenase activity
GO:0004029	aldehyde dehydrogenase (NAD) activity
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity
GO:0016491	oxidoreductase activity
GO:0046577	long-chain-alcohol oxidase activity
GO:0050061	long-chain-aldehyde dehydrogenase activity
GO:0052814	medium-chain-aldehyde dehydrogenase activity

Biological Process

GO:0006081	cellular aldehyde metabolic process
GO:0006714	sesquiterpenoid metabolic process
GO:0007417	central nervous system development
GO:0007422	peripheral nervous system development
GO:0008152	metabolic process
GO:0008218	bioluminescence
GO:0008544	epidermis development
GO:0033306	phytol metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005777	peroxisome
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1353452

InterPro

IPR008670 Acyl-CoA reductase, LuxC
IPR012394 Aldehyde dehydrogenase NAD(P)-dependent
IPR015590 Aldehyde dehydrogenase domain
IPR016161 Aldehyde/histidinol dehydrogenase

PFAM

PF05893
PF00171

PRINTS

PIRSF

PIRSF009414
PIRSF036492

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P47740