Version 5.4
Mus musculus Gene: Erc1
Summary
InnateDB Gene IDBG-182789.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Erc1
Gene Name ELKS/RAB6-interacting/CAST family member 1
Synonyms 4930404L01Rik; 5033405M01Rik; 9630025C19Rik; B430107L16Rik; CAST2; ELKS; mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B
Species Mus musculus
Ensembl Gene ENSMUSG00000030172
Encoded Proteins
IDBP-182791
ELKS/RAB6-interacting/CAST family member 1
IDBP-182793
ELKS/RAB6-interacting/CAST family member 1
IDBP-789125
ELKS/RAB6-interacting/CAST family member 1
IDBP-789128
ELKS/RAB6-interacting/CAST family member 1
IDBP-789130
ELKS/RAB6-interacting/CAST family member 1
IDBP-789132
ELKS/RAB6-interacting/CAST family member 1
IDBP-789134
ELKS/RAB6-interacting/CAST family member 1
IDBP-789136
ELKS/RAB6-interacting/CAST family member 1
IDBP-789137
ELKS/RAB6-interacting/CAST family member 1
IDBP-789139
ELKS/RAB6-interacting/CAST family member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000082805:
The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13) in thyroid papillary carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:119570796-119848167
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000032279 ENSMUSP00000032279
ENSMUST00000079582 ENSMUSP00000078534
ENSMUST00000183703 ENSMUSP00000139031
ENSMUST00000185139 ENSMUSP00000139152
ENSMUST00000184864 ENSMUSP00000139256
ENSMUST00000183880 ENSMUSP00000138823
ENSMUST00000184320 ENSMUSP00000139207
ENSMUST00000184838 ENSMUSP00000139030
ENSMUST00000183911 ENSMUSP00000139118
ENSMUST00000185143 ENSMUSP00000138989
ENSMUST00000183872
ENSMUST00000183741
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017137 Rab GTPase binding
Biological Process
GO:0007252 I-kappaB phosphorylation
GO:0015031 protein transport
GO:0042147 retrograde transport, endosome to Golgi
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0008385 IkappaB kinase complex
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000082805
View Gene Order
ENSBTAG00000013658
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
il1pathway
IL1-mediated signaling events
nfkappabcanonicalpathway
Canonical NF-kappaB pathway
Cross-References
SwissProt
TrEMBL V9GWT6
UniProt Splice Variant
Entrez Gene 111173
UniGene
RefSeq NM_053204 NM_178085 XM_006505370 XM_006505371 XM_006505372 XM_006505378
OMIM
CCDS CCDS20476 CCDS39611
HPRD
IMGT
MGI ID MGI:2151013
MGI Symbol Erc1
EMBL AC125102 AC128662 AC161060
GenPept
RNA Seq Atlas 111173

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca