InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Erc1

Summary

InnateDB Protein

IDBP-182793.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Erc1

Protein Name

ELKS/RAB6-interacting/CAST family member 1

Synonyms

4930404L01Rik; 5033405M01Rik; 9630025C19Rik; B430107L16Rik; CAST2; ELKS; mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000078534

InnateDB Gene

IDBG-182789 (Erc1)

Protein Structure

UniProt Annotation

Function

Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex (By similarity). May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000250}.

Subcellular Localization

Cytoplasm. Membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Note=In neurons, localized closed to presynaptic membrane. Recruited on Golgi membranes by RAB6A in a GTP-dependent manner.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:11929610}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017137	Rab GTPase binding

Biological Process

GO:0007252	I-kappaB phosphorylation
GO:0015031	protein transport
GO:0042147	retrograde transport, endosome to Golgi

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0008385	IkappaB kinase complex
GO:0045202	synapse

Protein Structure and Domains

PDB ID

MGI:2151013

InterPro

IPR019323 CAZ complex, RIM-binding protein

PFAM

PF10174

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99MI1

PhosphoSite

PhosphoSite-Q99MI1

TrEMBL

UniProt Splice Variant

Entrez Gene

111173

UniGene

Mm.288860

RefSeq

NP_835186

MGI ID

MGI Symbol

Erc1

OMIM

CCDS

CCDS20476

HPRD

IMGT

EMBL

AF340028 AF340029 AK048990 AK053824 AK122437 AY316692

GenPept

AAK26381 AAK26382 AAP83581 BAC33505 BAC35542 BAC65719