InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Slc16a1

Summary

InnateDB Gene

IDBG-182900.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc16a1

Gene Name

solute carrier family 16 (monocarboxylic acid transporters), member 1

Synonyms

AL022710; Mct1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032902

Encoded Proteins

IDBP-182902

solute carrier family 16 (monocarboxylic acid transporters), member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000155380:
The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:104638668-104658462

Strand

Forward strand

Band

F2.2

Transcripts

ENSMUST00000046212

ENSMUSP00000045216

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015293	symporter activity
GO:0015355	secondary active monocarboxylate transmembrane transporter activity
GO:0042803	protein homodimerization activity
GO:0097159	organic cyclic compound binding

Biological Process

GO:0006629	lipid metabolic process
GO:0015711	organic anion transport
GO:0032094	response to food
GO:0035873	lactate transmembrane transport
GO:0035879	plasma membrane lactate transport
GO:0042593	glucose homeostasis
GO:0050796	regulation of insulin secretion
GO:0051297	centrosome organization
GO:0051780	behavioral response to nutrient
GO:0055085	transmembrane transport
GO:0071407	cellular response to organic cyclic compound

Cellular Component

GO:0005739	mitochondrion
GO:0005813	centrosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome