InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC16A1

Summary

InnateDB Gene

IDBG-101192.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC16A1

Gene Name

solute carrier family 16, member 1 (monocarboxylic acid transporter 1)

Synonyms

HHF7; MCT; MCT1

Species

Homo sapiens

Ensembl Gene

ENSG00000155380

Encoded Proteins

IDBP-101194

solute carrier family 16, member 1 (monocarboxylic acid transporter 1)

IDBP-387767

solute carrier family 16, member 1 (monocarboxylic acid transporter 1)

IDBP-387768

solute carrier family 16, member 1 (monocarboxylic acid transporter 1)

IDBP-387769

solute carrier family 16, member 1 (monocarboxylic acid transporter 1)

IDBP-601543

solute carrier family 16, member 1 (monocarboxylic acid transporter 1)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:112911847-112957013

Strand

Reverse strand

Band

p13.2

Transcripts

ENST00000369626	ENSP00000358640
ENST00000458229	ENSP00000416167
ENST00000443580	ENSP00000399104
ENST00000429288	ENSP00000397106
ENST00000481750
ENST00000478835
ENST00000538576	ENSP00000441065

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008028	monocarboxylic acid transmembrane transporter activity
GO:0015130	mevalonate transmembrane transporter activity
GO:0015293	symporter activity
GO:0015355	secondary active monocarboxylate transmembrane transporter activity
GO:0042803	protein homodimerization activity
GO:0097159	organic cyclic compound binding

Biological Process

GO:0006090	pyruvate metabolic process
GO:0006629	lipid metabolic process
GO:0007596	blood coagulation
GO:0015711	organic anion transport
GO:0015718	monocarboxylic acid transport
GO:0015728	mevalonate transport
GO:0032094	response to food
GO:0035873	lactate transmembrane transport
GO:0035879	plasma membrane lactate transport
GO:0042593	glucose homeostasis
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0050796	regulation of insulin secretion
GO:0050900	leukocyte migration
GO:0051297	centrosome organization
GO:0051780	behavioral response to nutrient
GO:0055085	transmembrane transport
GO:0071407	cellular response to organic cyclic compound

Cellular Component

GO:0005739	mitochondrion
GO:0005813	centrosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome