Version 5.4
Mus musculus Gene: Gpr56
Summary
InnateDB Gene IDBG-183010.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gpr56
Gene Name G protein-coupled receptor 56
Synonyms Cyt28; TM7LN4; TM7XN1
Species Mus musculus
Ensembl Gene ENSMUSG00000031785
Encoded Proteins
IDBP-183014
G protein-coupled receptor 56
IDBP-716258
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000205336:
This gene encodes a member of the G protein-coupled receptor family. The protein contains 7 transmembrane domains and a mucin-like domain in the N-terminal region. The gene is implicated in the regulation of brain cortical patterning. The protein binds specifically to transglutaminase 2 in the extracellular space. Expression of this gene is downregulated in melanoma cell lines, and overexpression of this gene can suppress tumor growth and metastasis. Mutations in this gene result in bilateral frontoparietal polymicrogyria. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
This gene encodes a member of the G protein-coupled receptor family and regulates brain cortical patterning. The encoded protein binds specifically to transglutaminase 2, a component of tissue and tumor stroma implicated as an inhibitor of tumor progression. Mutations in this gene are associated with a brain malformation known as bilateral frontoparietal polymicrogyria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:94977109-95014208
Strand Forward strand
Band C5
Transcripts
ENSMUST00000093271 ENSMUSP00000090959
ENSMUST00000179619 ENSMUSP00000137520
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005518 collagen binding
GO:0050840 extracellular matrix binding
Biological Process
GO:0001525 angiogenesis
GO:0007155 cell adhesion
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007266 Rho protein signal transduction
GO:0007420 brain development
GO:0008285 negative regulation of cell proliferation
GO:0010573 vascular endothelial growth factor production
GO:0021801 cerebral cortex radial glia guided migration
GO:0021819 layer formation in cerebral cortex
GO:0035025 positive regulation of Rho protein signal transduction
GO:0045785 positive regulation of cell adhesion
GO:0070528 protein kinase C signaling
GO:2001223 negative regulation of neuron migration
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
GO:0097451 glial limiting end-foot
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000205336
View Gene Order
Cross-References
SwissProt Q8K209
TrEMBL
UniProt Splice Variant
Entrez Gene 14766
UniGene Mm.290834 Mm.405584
RefSeq NM_001198894 NM_018882 XM_006530678 XM_006530679 XM_006530680 XM_006530681 XM_006530682 XM_006530683 XM_006530684 XM_006530685 XM_006530686 XM_006530687 XM_006530688 XM_006530689 XM_006530690 XM_006530691 XM_006530692 XM_006530693 XM_006530694 XM_006530695 XM_006530696 XM_006530697
OMIM
CCDS CCDS22553
HPRD
IMGT
MGI ID MGI:1340051
MGI Symbol Gpr56
EMBL AF166382 AK087268 AK133678 AK141886 AK141894 AK167547 BC034678
GenPept AAF00617 AAH34678 BAC39835 BAE21780 BAE24871 BAE24874 BAE39613
RNA Seq Atlas 14766

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca