InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gpr56

Summary

InnateDB Protein

IDBP-183014.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gpr56

Protein Name

G protein-coupled receptor 56

Synonyms

Cyt28; TM7LN4; TM7XN1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000090959

InnateDB Gene

IDBG-183010 (Gpr56)

Protein Structure

UniProt Annotation

Function

Involved in cell adhesion and probably in cell-cell interactions. Regulates the migration of neural precursor cells. Receptor for collagen III/Col3a1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basemant membrane integrity and in cortical lamination. Binding to the Col3a1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to Gna13 and possibly Gna12. Required for normal cortical development and regulation of neuroprogenitor cells proliferation. {ECO:0000269PubMed:18378689, ECO:0000269PubMed:18509043, ECO:0000269PubMed:19515912, ECO:0000269PubMed:21768377, ECO:0000269PubMed:24531968}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:17576745}; Multi-pass membrane protein {ECO:0000269PubMed:17576745}.GPR56 N-terminal fragment: Secreted.

Disease Associations

Tissue Specificity

Expressed in neural progenitor cells in fetal forbrain. Expressed in migrating neurons. Expressed in radial glial endfeet (at protein level). {ECO:0000269PubMed:21768377}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005518	collagen binding
GO:0050840	extracellular matrix binding

Biological Process

GO:0001525	angiogenesis
GO:0007155	cell adhesion
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007266	Rho protein signal transduction
GO:0008285	negative regulation of cell proliferation
GO:0010573	vascular endothelial growth factor production
GO:0021801	cerebral cortex radial glia guided migration
GO:0021819	layer formation in cerebral cortex
GO:0035025	positive regulation of Rho protein signal transduction
GO:0045785	positive regulation of cell adhesion
GO:0070528	protein kinase C signaling
GO:2001223	negative regulation of neuron migration