Version 5.4
Mus musculus Gene: Cdkl5
Summary
InnateDB Gene IDBG-183150.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdkl5
Gene Name cyclin-dependent kinase-like 5
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000031292
Encoded Proteins
IDBP-183152
cyclin-dependent kinase-like 5
IDBP-256172
cyclin-dependent kinase-like 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000008086:
This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:160784308-160994702
Strand Reverse strand
Band F4
Transcripts
ENSMUST00000087104 ENSMUSP00000084342
ENSMUST00000112355 ENSMUSP00000107974
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0048365 Rac GTPase binding
Biological Process
GO:0001764 neuron migration
GO:0006468 protein phosphorylation
GO:0007049 cell cycle
GO:0016310 phosphorylation
GO:0032855 positive regulation of Rac GTPase activity
GO:0045773 positive regulation of axon extension
GO:0046777 protein autophosphorylation
GO:0050773 regulation of dendrite development
GO:0050775 positive regulation of dendrite morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0032587 ruffle membrane
GO:0032839 dendrite cytoplasm
GO:0044294 dendritic growth cone
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000008086
View Gene Order
ENSBTAG00000007428
Not yet available
Cross-References
SwissProt Q3UTQ8
TrEMBL
UniProt Splice Variant
Entrez Gene 382253
UniGene Mm.443717
RefSeq NM_001024624
OMIM
CCDS CCDS53238
HPRD
IMGT
MGI ID MGI:1278336
MGI Symbol Cdkl5
EMBL AK052380 AK139220 BC042705
GenPept AAH42705 BAC34965 BAE23922
RNA Seq Atlas 382253

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca