InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdkl5

Summary

InnateDB Protein

IDBP-183152.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdkl5

Protein Name

cyclin-dependent kinase-like 5

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000084342

InnateDB Gene

IDBG-183150 (Cdkl5)

Protein Structure

UniProt Annotation

Function

Mediates phosphorylation of MECP2. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0048365	Rac GTPase binding

Biological Process

GO:0001764	neuron migration
GO:0006468	protein phosphorylation
GO:0007049	cell cycle
GO:0032855	positive regulation of Rac GTPase activity
GO:0045773	positive regulation of axon extension
GO:0046777	protein autophosphorylation
GO:0050773	regulation of dendrite development
GO:0050775	positive regulation of dendrite morphogenesis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0032587	ruffle membrane
GO:0032839	dendrite cytoplasm
GO:0044294	dendritic growth cone

Protein Structure and Domains

PDB ID

MGI:1278336

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt