InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CREB3L3

Summary

InnateDB Gene

IDBG-18336.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CREB3L3

Gene Name

cAMP responsive element binding protein 3-like 3

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000060566

Encoded Proteins

IDBP-18338

cAMP responsive element binding protein 3-like 3

IDBP-760519

IDBP-760876

IDBP-764794

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:4153601-4173054

Strand

Forward strand

Band

p13.3

Transcripts

ENST00000078445	ENSP00000078445
ENST00000602147	ENSP00000470119
ENST00000598894
ENST00000602257	ENSP00000472399
ENST00000595923	ENSP00000469355

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006986	response to unfolded protein
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000035041

View Gene Order

ENSBTAG00000010215

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa05215

Prostate cancer pathway

hsa04916

Melanogenesis pathway

hsa05016

Huntington's disease pathway

hsa04962

Vasopressin-regulated water reabsorption pathway

INOH

PID NCI

Cross-References

SwissProt

Q68CJ9

TrEMBL

M0QYW7

UniProt Splice Variant

Entrez Gene

84699

UniGene

Hs.247744

RefSeq

NM_001271995 NM_001271996 NM_001271997 NM_032607

HUGO

HGNC:18855

OMIM

611998

CCDS

CCDS12121 CCDS62498 CCDS62499 CCDS62500

HPRD

IMGT

EMBL

AB050902 AB073612 AC016586 AK172839 AK313099 BC101504 BC101508 BC143609 CH471139

GenPept

AAI01505 AAI01509 AAI43610 BAB47242 BAD18804 BAD38649 BAG35923 EAW69260

RNA Seq Atlas

84699